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Titolo:
Electrospray ionization and matrix-assisted laser desorption ionization mass spectrometry - Emerging technologies in biomedical sciences
Autore:
Bakhtiar, R; Nelson, RW;
Indirizzi:
Stevens Inst Technol, Dept Chem & Chem Engn, Hoboken, NJ 07030 USA StevensInst Technol Hoboken NJ USA 07030 hem Engn, Hoboken, NJ 07030 USA Intrins Bioprobes Inc, Tempe, AZ 85281 USA Intrins Bioprobes Inc Tempe AZUSA 85281 oprobes Inc, Tempe, AZ 85281 USA
Titolo Testata:
BIOCHEMICAL PHARMACOLOGY
fascicolo: 8, volume: 59, anno: 2000,
pagine: 891 - 905
SICI:
0006-2952(20000415)59:8<891:EIAMLD>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIOMOLECULAR INTERACTION ANALYSIS; SURFACE-PLASMON RESONANCE; MECHANISM-BASED INACTIVATION; PROTEIN CHARACTERIZATION; NONCOVALENT COMPLEXES; COMBINATORIAL CHEMISTRY; BINDING CONSTANTS; DRUG-METABOLISM; LIGAND-BINDING; IN-VIVO;
Keywords:
proteomics; non-covalent complexes; sequencing; high throughput mass spectrometry; combinatorial chemistry; biomolecular interaction analysis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
158
Recensione:
Indirizzi per estratti:
Indirizzo: Bakhtiar, R Novartis Pharma, DMPK Dept, Bldg 405,Room 229,59 Route 10, E Hanover, NJ 07936 USA Novartis Pharma Bldg 405,Room 229,59 Route 10 E Hanover NJ USA 07936
Citazione:
R. Bakhtiar e R.W. Nelson, "Electrospray ionization and matrix-assisted laser desorption ionization mass spectrometry - Emerging technologies in biomedical sciences", BIOCH PHARM, 59(8), 2000, pp. 891-905

Abstract

Tremendous progress in biomedical sciences has been made possible in part by recent advances in bioanalytical methods, in particular biological mass spectrometry. Since the introduction of electrospray ionization mass spectrometry (ESI-MS) in 1984 and matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS) in 1988, the field of bioanalytical mass spectrometry has seen rapid growth. In concert with separation techniques such as capillary electrophoresis and high performance liquid chromatography, mass spectrometry allows characterization of a large array of small organic molecules, peptides, proteins, oligonucleotides, and RNA fragments. Thus, substantially more expedient and definitive determination of molecular weight is now possible by mass spectrometric analysis. In this commentary, general descriptions of ESI- and MALDI-MS are presented. Furthermore, several recent developments and applications in addressing difficult biological problems are discussed. (C) 2000 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 01:51:27