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Titolo:
Mouse peroxiredoxin V is a thioredoxin peroxidase that inhibits p53-induced apoptosis
Autore:
Zhou, Y; Kok, KH; Chun, ACS; Wong, CM; Wu, HW; Lin, MCM; Fung, PCW; Kung, HF; Jin, DY;
Indirizzi:
Univ Hong Kong, Inst Mol Biol, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples R China Univ Hong Kong, Dept Med, Div Med Phys, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples R China
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 3, volume: 268, anno: 2000,
pagine: 921 - 927
SICI:
0006-291X(20000224)268:3<921:MPVIAT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
THIOL-SPECIFIC ANTIOXIDANT; NF-KAPPA-B; ESCHERICHIA-COLI; MAMMALIAN PEROXIREDOXIN; GLUTATHIONE-PEROXIDASE; SEQUENCE-ANALYSIS; SCAVENGASE P20; FAMILY; IDENTIFICATION; REDUCTASE;
Keywords:
peroxiredoxin; thioredoxin peroxidase; p53; apoptosis; redox; reactive oxygen species (ROS);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Jin, DY Univ Hong Kong, Inst Mol Biol, 8-F Kadoorie Biol Sci Bldg,PokfulamRd, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong 8-F Kadoorie BiolSci Bldg,Pokfulam Rd Hong Kong Hong Kong Peoples R China
Citazione:
Y. Zhou et al., "Mouse peroxiredoxin V is a thioredoxin peroxidase that inhibits p53-induced apoptosis", BIOC BIOP R, 268(3), 2000, pp. 921-927

Abstract

We have identified human and mouse peroxiredoxin V (Prx-V) by virtue of the sequence homologies to yeast peroxisomal antioxidant enzyme PMP20. Prx-V represents the fifth of the six currently known subfamilies of mammalian peroxiredoxins. It is a novel organellar enzyme that has orthologs in bacteria. Biochemically, Prx-V is a thioredoxin peroxidase. One important aspect of p53 function in mammalian cells involves induction of apoptosis likely mediated by redox. We show that overexpression of Prx-V prevented the p53-dependent generation of reactive oxygen species. Likewise, Prx-V inhibited p53-induced apoptosis. Thus, Prx-V is critically involved in intracellular redox signaling. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 04:41:52