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Titolo:
Clinical value of [18-F] fluorodeoxyglucose positron emission tomography imaging in soft tissue sarcomas
Autore:
Schwarzbach, MHM; Dimitrakopoulou-Strauss, A; Willeke, F; Hinz, U; Strauss, LG; Zhang, YM; Mechtersheimer, G; Attigah, N; Lehnert, T; Herfarth, C;
Indirizzi:
Univ Heidelberg, Dept Surg, D-69120 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-69120 , D-69120 Heidelberg, Germany Univ Heidelberg, Div Surg Oncol, D-69120 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-69120 , D-69120 Heidelberg, Germany Univ Heidelberg, Inst Pathol, D-69120 Heidelberg, Germany Univ HeidelbergHeidelberg Germany D-69120 , D-69120 Heidelberg, Germany German Canc Res Ctr, D-6900 Heidelberg, Germany German Canc Res Ctr Heidelberg Germany D-6900 D-6900 Heidelberg, Germany
Titolo Testata:
ANNALS OF SURGERY
fascicolo: 3, volume: 231, anno: 2000,
pagine: 380 - 386
SICI:
0003-4932(200003)231:3<380:CVO[FP>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
F-18 FLUORODEOXYGLUCOSE; MUSCULOSKELETAL TUMORS; COMPUTED-TOMOGRAPHY; COLORECTAL-CANCER; PET; FDG; METASTASES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Schwarzbach, MHM Univ Heidelberg, Dept Surg, Neuenheimer Feld 110, D-69120Heidelberg, Germany Univ Heidelberg Neuenheimer Feld 110 Heidelberg Germany D-69120
Citazione:
M.H.M. Schwarzbach et al., "Clinical value of [18-F] fluorodeoxyglucose positron emission tomography imaging in soft tissue sarcomas", ANN SURG, 231(3), 2000, pp. 380-386

Abstract

ObjectiveTo evaluate positron emission tomography (PET) using 2-fluoro-2-deoxy-D-glucose (FDG) for clinical application in soft tissue sarcomas. Summary and Background DataFDG PET is a promising noninvasive method for the preoperative assessment of soft tissue sarcomas and may complement radiologic tomography. MethodsData from 50 consecutive patients with 59 masses, either suspicious for primary or locally recurrent soft tissue sarcoma, were prospectively gathered. The semiquantitative FDG uptake (standardized uptake values [SUVs]) was calculated in tumor and normal tissue (muscle). Histopathology of surgical specimens and follow-up data were used as control criteria. ResultsIn primary soft tissue sarcomas, PET displayed a sensitivity of 91% and a specificity of 88%. Local recurrence was detected with a sensitivity of 88%and a specificity of 92%, All intermediate-grade and high-grade soft tissue sarcomas (primary and locally recurrent) were Visualized with a precise differentiation from muscle, Fifty percent of the low-grade sarcomas showed an FDG uptake equivalent to muscle (false-negative results in one primary and three recurrent soft tissue sarcomas). Benign soft tissue tumors (e.g., lipoma, leiomyoma, ganglion) did not accumulate FDG. inflammation resulted in an increased FDG uptake. The semiquantitative FDG uptake (SUVs) correlated with tumor grade but not with size and histologic type. ConclusionHigh-grade and intermediate-grade soft tissue sarcomas are amenable to PETimaging, whereas low-grade lesions may not be depicted, SUVs for FDG correlate with tumor grade in soft tissue sarcomas, Benign soft tissue tumors are differentiated from higher-grade soft tissue sarcomas. These data show that FDG-PET can complement preoperative radiologic assessment for soft tissue sarcomas and that FDG-PET is a powerful diagnostic toot for detecting high-grade and intermediate-grade local recurrence.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 12:12:40