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Titolo:
Treatment for posttraumatic stress disorder
Autore:
Cyr, M; Farrar, MK;
Indirizzi:
Univ Tennessee, Coll Pharm, Dept Pharmacoecon & Pharm Practice, Memphis, TN 38163 USA Univ Tennessee Memphis TN USA 38163 Pharm Practice, Memphis, TN 38163 USA Univ Tennessee, Coll Pharm, Vet Affairs Med Ctr, Memphis, TN 38163 USA Univ Tennessee Memphis TN USA 38163 ffairs Med Ctr, Memphis, TN 38163 USA Vet Affairs Med Ctr, Posttraumat Stress Disorder Clin, Mental Hlth Serv 116A, Memphis, TN USA Vet Affairs Med Ctr Memphis TN USA ental Hlth Serv 116A, Memphis, TN USA
Titolo Testata:
ANNALS OF PHARMACOTHERAPY
fascicolo: 3, volume: 34, anno: 2000,
pagine: 366 - 376
SICI:
1060-0280(200003)34:3<366:TFPSD>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRAUMATIC WAR NEUROSIS; MONOAMINE-OXIDASE INHIBITORS; OPEN TRIAL; COMBAT VETERANS; FLUVOXAMINE TREATMENT; HIPPOCAMPAL VOLUME; PTSD; PHENELZINE; FLUOXETINE; NIGHTMARES;
Keywords:
posttraumatic stress disorder; pharmacotherapy; antidepressants;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
98
Recensione:
Indirizzi per estratti:
Indirizzo: Cyr, M Univ Tennessee, Coll Pharm, Dept Pharmacoecon & Pharm Practice, 3 NDunlapSt, Memphis, TN 38163 USA Univ Tennessee 3 N Dunlap St Memphis TN USA 38163 his, TN 38163 USA
Citazione:
M. Cyr e M.K. Farrar, "Treatment for posttraumatic stress disorder", ANN PHARMAC, 34(3), 2000, pp. 366-376

Abstract

OBJECTIVE: To thoroughly and critically review the pharmacologic treatmentof posttraumatic stress disorder (PTSD) and to review the symptomatology, diagnosis, epidemiology, pathophysiology, and assessment of PTSD. DATA SOURCES: A MEDLINE search (1966-October 1999) in the English languagespecific PTSD drug treatment as the search term was used to identify articles. STUDY SELECTION AND DATA EXTRACTION: All articles identified were reviewed; emphasised was given to randomized, double-blind placebo-controlled studies, DATA SYNTHESIS: It appears that a five-week medication trial is necessary to assess clinical effects on PTSD symptoms. The monoamine oxidase inhibitors appear to be superior to the tricyclic antidepressants in improving reexperiencing and avoidance symptoms. Most studies used assessment tools that neglected hyperarousal symptoms; therefore, no conclusions regarding this symptoms cluster can be drawn. Other pharmacotherapeutic interventions reported in open-label trials have yielded varying successCONCLUSIONS: The current literature does not bear a sufficient number of double-blind, placebo-controlled studied using assessment tools that evaluate the three symptom clusters of PTSD to allow for a definite treatment modality to be formulated. Nonetheless, a treatment hierarchy appears to be in order based on the greatest number of double-blind, placebo-controlled studies evaluating antidepressants. Alternate modalities such as mood stabilizers, antipsychotics, anxiolytics, and adrenergic blockers should not be considered the mainstays of therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:26:24