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Titolo:
Doxepin toxicity in a child following topical administration
Autore:
Zell-Kanter, M; Toerne, TS; Spiegel, K; Negrusz, A;
Indirizzi:
Cook Cty Hosp, Div Occupat Med, Toxikon Consortium, Chicago, IL 60612 USA Cook Cty Hosp Chicago IL USA 60612 ikon Consortium, Chicago, IL 60612 USA Univ Mississippi, Med Ctr, Mississippi Poison Ctr, Dept Emergency Med, Jackson, MS 39216 USA Univ Mississippi Jackson MS USA 39216 mergency Med, Jackson, MS 39216 USA Northwestern Univ, Dept Biochem Mol Biol & Cell Biol, Keck Biophys Facil, Evanston, IL USA Northwestern Univ Evanston IL USA , Keck Biophys Facil, Evanston, IL USA Univ Illinois, Coll Pharm, Dept Pharmaceut & Pharmacodynam, Chicago, IL USA Univ Illinois Chicago IL USA Pharmaceut & Pharmacodynam, Chicago, IL USA
Titolo Testata:
ANNALS OF PHARMACOTHERAPY
fascicolo: 3, volume: 34, anno: 2000,
pagine: 328 - 329
SICI:
1060-0280(200003)34:3<328:DTIACF>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Keywords:
doxepin; tricyclic antidepressants; eczema; adverse effects;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Zell-Kanter, M Cook Cty Hosp, Div Occupat Med, Toxikon Consortium, 1900 W Polk St,Ste 500, Chicago, IL 60612 USA Cook Cty Hosp 1900 W Polk St,Ste 500Chicago IL USA 60612 A
Citazione:
M. Zell-Kanter et al., "Doxepin toxicity in a child following topical administration", ANN PHARMAC, 34(3), 2000, pp. 328-329

Abstract

OBJECTIVE: To describe a case of a child with altered mental status following the topical administration of doxepin. CASE SUMMARY: A five-year-old Hispanic girl was brought tb the emergency department because she was difficult to arouse at school. She had recently developed a generalized eczematous rash for which she. was prescribed doxepin hydrochloride 5% cream. An entire tube (30 g) of doxepin dream was applied in the 24 hours prior to presentation. The patient was responsive only tonoxious stimuli, with no focal neurologic abnormalities. She was decontaminated and observed in a pediatric intensive care unit. By 18 hours after presentation, she had fully recovered and was discharged. CONCLUSIONS: Topical doxepin, available as a 5% cream, is indicated for the treatment of pruritus secondary to eczematous dermatoses in adults. Diminished skin integrity and the application of a massive quantity of doxepin 5% cream to a large body surface area contributed to the toxicity in this child. Since the safety and efficacy of doxepin cream has not been established in children younger than 12 years, it should be used with caution in thispopulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:15:36