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Titolo:
Applications of SPECT imaging of dopaminergic neurotransmission in neuropsychiatric disorders
Autore:
Kugaya, A; Fujita, M; Innis, RB;
Indirizzi:
Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA Yale Univ New Haven CT USA iv, Sch Med, Dept Psychiat, New Haven, CT USA Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA Yale Univ New Haven CT USA iv, Sch Med, Dept Psychiat, New Haven, CT USA Yale Univ, Sch Med, Dept Pharmacol, New Haven, CT 06510 USA Yale Univ NewHaven CT USA 06510 Dept Pharmacol, New Haven, CT 06510 USA
Titolo Testata:
ANNALS OF NUCLEAR MEDICINE
fascicolo: 1, volume: 14, anno: 2000,
pagine: 1 - 9
SICI:
0914-7187(200002)14:1<1:AOSIOD>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; NAIVE SCHIZOPHRENIC-PATIENTS; PARKINSONS-DISEASE; RECEPTOR-BINDING; COMPUTERIZED-TOMOGRAPHY; ENDOGENOUS DOPAMINE; NONHUMAN-PRIMATES; UPTAKE SITES; HUMAN BRAIN; D-2;
Keywords:
single photon emission computed tomography (SPECT); dopamine; Parkinson's disease; schizophrenia;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Innis, RB VA Connecticut, 116A2,950 Campbell Ave, W Haven, CT 06516 USA VAConnecticut 116A2,950 Campbell Ave W Haven CT USA 06516 6 USA
Citazione:
A. Kugaya et al., "Applications of SPECT imaging of dopaminergic neurotransmission in neuropsychiatric disorders", ANN NUCL M, 14(1), 2000, pp. 1-9

Abstract

Single photon emission computed tomography (SPECT) tracers selective for pre- and post-synaptic targets have allowed measurements of several aspects of dopaminergic (DA) neurotransmission. In this article, we will first review our DA transporter imaging in Parkinson's disease. We have developed thein vivo dopamine transporter(DAT) imaging with [I-123]beta-CIT ((1R)-2 beta-Carbomethoxy-3 beta-(4-iodophenyl)tropane). This method showed that patients with Parkinson's disease have markedly reduced DAT levels in striatum, which correlated with disease severity and disease progression. Second, we applied DA imaging techniques in patients with schizophrenia. Using amphetamine as a releaser of DA, we observed the enhanced DA release, which was measured by imaging D2 receptors with [I-123]IBZM (iodobenzamide), in schizophrenics. Further we developed the measurement of basal synaptic DA levels by AMPT (alpha-methyl-paratyrosine)-induced unmasking of D2 receptors. Finally, we expanded our techniques to the measurement of extrastriatal DA receptors using [I-123]epidepride. The findings suggest that SPECT is a useful technique to measure DA transmission in human brain and may further our understanding of the pathophysiology of neuropsychiatric disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 01:32:51