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Titolo:
Altered circulating levels of adhesion molecules at 18 weeks' gestation among women with eventual preeclampsia: Indicators of disturbed placentation in absence of evidence of endothelial dysfunction?
Autore:
Clausen, T; Djurovic, S; Brosstad, FR; Berg, K; Henriksen, T;
Indirizzi:
Univ Oslo, Natl Hosp, Dept Obstet & Gynecol, N-0027 Oslo, Norway Univ Oslo Oslo Norway N-0027 Dept Obstet & Gynecol, N-0027 Oslo, Norway Univ Oslo, Inst Nutr Res, Oslo, Norway Univ Oslo Oslo NorwayUniv Oslo, Inst Nutr Res, Oslo, Norway Aker Univ Hosp, Dept Obstet & Gynecol, Oslo, Norway Aker Univ Hosp Oslo Norway iv Hosp, Dept Obstet & Gynecol, Oslo, Norway Ulleval Univ Hosp, Dept Med Genet, Oslo, Norway Ulleval Univ Hosp Oslo Norway l Univ Hosp, Dept Med Genet, Oslo, Norway Ulleval Univ Hosp, Inst Med Genet, Oslo, Norway Ulleval Univ Hosp Oslo Norway l Univ Hosp, Inst Med Genet, Oslo, Norway Univ Oslo, Natl Hosp, Internal Med Res Inst, N-0027 Oslo, Norway Univ Oslo Oslo Norway N-0027 Internal Med Res Inst, N-0027 Oslo, Norway
Titolo Testata:
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
fascicolo: 2, volume: 182, anno: 2000,
pagine: 321 - 325
SICI:
0002-9378(200002)182:2<321:ACLOAM>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREGNANCY-INDUCED HYPERTENSION; INCREASED PLASMA-LEVELS; CELLULAR FIBRONECTIN; HUMAN CYTOTROPHOBLASTS; ENDOVASCULAR INVASION; VONWILLEBRAND-FACTOR; SERUM; PHENOTYPE; MARKERS; ICAM-1;
Keywords:
adhesion molecules; endothelial dysfunction; placentation; preeclampsia; von Willebrand factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Henriksen, T Univ Oslo, Natl Hosp, Dept Obstet & Gynecol, N-0027 Oslo, Norway Univ Oslo Oslo Norway N-0027 & Gynecol, N-0027 Oslo, Norway
Citazione:
T. Clausen et al., "Altered circulating levels of adhesion molecules at 18 weeks' gestation among women with eventual preeclampsia: Indicators of disturbed placentation in absence of evidence of endothelial dysfunction?", AM J OBST G, 182(2), 2000, pp. 321-325

Abstract

OBJECTIVE: The purpose of this study was to investigate whether indications of activation of the maternal endothelium were present at 18 weeks' gestation in women in whom preeclampsia eventually developed. STUDY DESIGN: A total of 2190 blood samples were obtained at 18 weeks' gestation. Circulating levels of von Willebrand factor and soluble vascular adhesion molecule 1, soluble intercellular adhesion molecule 1, and E-selectin were assayed in 71 women with eventual preeclampsia and 71 control subjects. RESULTS: E-selectin and von Willebrand factor levels were similar between the 2 groups. Soluble vascular adhesion molecule 1 concentration was significantly lower in the women with eventual preeclampsia (median, 649.0 ng/mL vs 762.4 ng/mL; P<.001), whereas soluble intercellular adhesion molecule 1 concentration was significantly higher (median, 239.8 ng/mL vs 178.3 ng/mL;P<.001). CONCLUSION: We found no indications of endothelial activation at 18 weeks'gestation in women in whom preeclampsia later developed. However, decreased serum concentration of soluble vascular adhesion molecule 1 and increasedserum concentration of soluble intercellular adhesion molecule 1 may reflect the disturbed placentation known to be associated with the development of preeclampsia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 14:27:19