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Titolo:
D-1 dopamine receptor signalling defect in spontaneous hypertension
Autore:
Felder, RA; Eisner, GM; Jose, PA;
Indirizzi:
Georgetown Univ, Med Ctr, Dept Pediat & Physiol & Biophys, Washington, DC 20007 USA Georgetown Univ Washington DC USA 20007 Biophys, Washington, DC 20007 USA Univ Virginia, Hlth Sci Ctr, Dept Pathol, Charlottesville, VA USA Univ Virginia Charlottesville VA USA ept Pathol, Charlottesville, VA USA Washington Hosp Ctr, Dept Med, Washington, DC USA Washington Hosp Ctr Washington DC USA Ctr, Dept Med, Washington, DC USA
Titolo Testata:
ACTA PHYSIOLOGICA SCANDINAVICA
fascicolo: 1, volume: 168, anno: 2000,
pagine: 245 - 250
SICI:
0001-6772(200001)168:1<245:DDRSDI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROXIMAL CONVOLUTED TUBULE; SALT-SENSITIVE RATS; BLOOD-PRESSURE; ANGIOTENSIN-II; GENETIC-HYPERTENSION; PARATHYROID-HORMONE; URINARY DOPAMINE; VOLUME EXPANSION; EXCRETION; NATRIURESIS;
Keywords:
cAMP; cortical collecting duct; dopamine receptors; dopamine; G protein-related kinase; hypertension; medullary thick ascending limb of Henle; Na+/K(+)ATPase; proximal tubule; signal transduction; sodium/hydrogen exchanger;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Jose, PA Georgetown Univ, Med Ctr, Dept Pediat & Physiol & Biophys, 3800 Reservoir Rd NW, Washington, DC 20007 USA Georgetown Univ 3800 Reservoir Rd NW Washington DC USA 20007 USA
Citazione:
R.A. Felder et al., "D-1 dopamine receptor signalling defect in spontaneous hypertension", ACT PHYSL S, 168(1), 2000, pp. 245-250

Abstract

Dopamine modulates cardiovascular function by actions in the central and peripheral nervous system, by altering the secretion/release of prolactin, pro-opiomelanocortin, vasopressin, aldosterone, and renin, and by directly affecting renal function. Dopamine produced by the renal proximal tubule exerts an autocrine/paracrine action via two classes of dopamine receptors, D-1-like (D-1 and D-5) and D-2-like (D-2, D-3, and D-4), that are differentially expressed along the nephron. The autocrine/paracrine function of dopamine, manifested by tubular rather than by haemodynamic mechanisms, becomes most evident during extracellular fluid volume expansion. This renal autocrine/paracrine function is lost in essential hypertension and in some animal models of genetic hypertension. The molecular basis for the dopaminergic dysfunction in hypertension may involve an abnormal post-translational modification of dopamine receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:25:33