Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Dynamics of dominance of a dipeptide insertion in reverse transcriptase ofHIV-1 from patients subjected to prolonged therapy
Autore:
Briones, C; Mas, A; Gomez-Mariano, G; Altisent, C; Menedez-Arias, L; Soriano, V; Domingo, E;
Indirizzi:
Univ Autonoma Madrid, CSIC, Ctr Biol Mol Severo Ochoa, E-28049 Madrid, Spain Univ Autonoma Madrid Madrid Spain E-28049 o Ochoa, E-28049 Madrid, Spain Hosp Carlos III, Inst Salud Carlos III, Infect Dis Serv, Madrid, Spain Hosp Carlos III Madrid Spain Carlos III, Infect Dis Serv, Madrid, Spain Hosp Valle Hebro, Hemophilia Unit, Barcelona, Spain Hosp Valle Hebro Barcelona Spain bro, Hemophilia Unit, Barcelona, Spain
Titolo Testata:
VIRUS RESEARCH
fascicolo: 1, volume: 66, anno: 2000,
pagine: 13 - 26
SICI:
0168-1702(200001)66:1<13:DODOAD>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; HIGH-LEVEL RESISTANCE; DRUG-RESISTANCE; COMBINATION THERAPY; POL GENE; IN-VIVO; ANTIRETROVIRAL THERAPY; POPULATION-DYNAMICS; PROTEASE INHIBITOR; NUCLEOSIDE ANALOGS;
Keywords:
AIDS; mutation; quasispecies complexity; HIV evolution;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Domingo, E Univ Autonoma Madrid, CSIC, Ctr Biol Mol Severo Ochoa, E-28049 Madrid, Spain Univ Autonoma Madrid Madrid Spain E-28049 28049 Madrid, Spain
Citazione:
C. Briones et al., "Dynamics of dominance of a dipeptide insertion in reverse transcriptase ofHIV-1 from patients subjected to prolonged therapy", VIRUS RES, 66(1), 2000, pp. 13-26

Abstract

A small proportion (0.8%) of individuals of a cohort of HIV-1 infected patients subjected to prolonged therapy with nucleoside analogues included a recently recognised dipeptide insertion in their RT (Ser-Ser or Ser-Gly between RT codons 69 and 70). To study the dynamics of dominance of genomes with this genetic change, sequential HIV-1 isolates from two patients were analyzed with regard to consensus sequences and complexity of mutant spectra. The two patients displayed completely different, complex evolutionary patterns leading to temporary dominance of dipeptide insertions. In one patient,a virus very closely related to an ancestor virus from the same patient overtook the population at late;times, displacing genomes encoding a Ser-Ser insertion. In another patient the sequential dominance of genomes with Ser-Ser insertion --> no insertion --> Ser-Gly insertion was observed. These three types of genomes coexisted in the mutant spectrum of one HIV-1 isolate. Complexity was also reflected in the shape of phylogenetic trees derived with genomes from the mutant spectrum at each time point. The results suggest that HIV-1 genomes encoding a dipeptide insertion between RT codons 69 and 70 do not show a clear selective advantage over other genomes lacking theinsertion. Such an absence of a clear selective advantage will favor that such genomes encoding this RT insertion become dominant only in a transientfashion, and following disparate kinetics in different patients. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:21:06