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Titolo:
HLA-A*2416: a new allele of the HLA-A19 lineage
Autore:
Binder, T; Heym, J; Horn, B; Blasczyk, R;
Indirizzi:
Hannover Med Sch, Dept Transfus Med, D-30625 Hannover, Germany Hannover Med Sch Hannover Germany D-30625 Med, D-30625 Hannover, Germany Univ Jena, Inst Transfus Med, D-6900 Jena, Germany Univ Jena Jena Germany D-6900 a, Inst Transfus Med, D-6900 Jena, Germany
Titolo Testata:
TISSUE ANTIGENS
fascicolo: 2, volume: 55, anno: 2000,
pagine: 178 - 181
SICI:
0001-2815(200002)55:2<178:HANAOT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Keywords:
HLA-A*2416; sequencing based typing (SBT); HLA nomenclature;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
6
Recensione:
Indirizzi per estratti:
Indirizzo: Blasczyk, R Hannover Med Sch, Dept Transfus Med, Carl Neuberg Str 1, D-30625 Hannover,Germany Hannover Med Sch Carl Neuberg Str 1 Hannover Germany D-30625
Citazione:
T. Binder et al., "HLA-A*2416: a new allele of the HLA-A19 lineage", TISSUE ANTI, 55(2), 2000, pp. 178-181

Abstract

We here report on a new HLA-A19 allele (A*2416) found in a German kidney recipient, Serological class I typing revealed HLA-A11,19 without clear definition of the A19 split antigen. As with serology, polymerase chain reaction (PCR)-based typing also revealed inconclusive results. We therefore sequenced the gene from the 5' flanking region through the 3'-end of exon 4 of this allele after haplotype-specific PCR amplification. The sequence analysis revealed a new HLA-A allele which is identical to A*3101 with the exception of the 3' half of exon 2 which is identical tu the common A9 alleles. The phylogenetic analysis constructed with the nearest neighbor algorithm andbased on exons 1-4 or introns 1-3 clearly indicated, that A*2416 belongs unequivocally to the A19 lineage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 13:45:13