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Titolo:
The role of membrane-associated adaptors in T cell receptor signalling
Autore:
Zhang, WG; Samelson, LE;
Indirizzi:
NCI, Cellular & Mol Biol Lab, Div Basic Sci, NIH, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 Lab, Div Basic Sci, NIH, Bethesda, MD 20892 USA
Titolo Testata:
SEMINARS IN IMMUNOLOGY
fascicolo: 1, volume: 12, anno: 2000,
pagine: 35 - 41
SICI:
1044-5323(200002)12:1<35:TROMAI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-TYROSINE KINASES; NATURAL-KILLER-CELLS; ANTIGEN RECEPTOR; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHOLIPASE C-GAMMA-1; SIGNALING PROTEINS; RAS PATHWAY; P85 SUBUNIT; SH3 DOMAIN; ACTIVATION;
Keywords:
Gads; Grb2; PLC-gamma 1;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Samelson, LE NCI, Cellular & Mol Biol Lab, Div Basic Sci, NIH, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 c Sci, NIH, Bethesda, MD 20892 USA
Citazione:
W.G. Zhang e L.E. Samelson, "The role of membrane-associated adaptors in T cell receptor signalling", SEMIN IMMUN, 12(1), 2000, pp. 35-41

Abstract

Engagement of the T cell receptor lends to activation of several tyrosine kinases and phosphorylation of many intracellular;proteins. This is followed by Ca2+ mobilization and activation of multiple biochemical pathways, including the Ras/MAPK cascade, and several downstream serine/ threonine kinases. Membrane-associated adaptor proteins play an important role in T cell activation by coupling TCR ligation at the membrane to distal signalling cascades. Several new membrane associated adaptors have been identified in recent years. LAT (linker for activation of T cells) is an adaptor molecule, which following its phosphorylation associates with Grb2, Gads, PLC-gamma 1,and other signalling molecules. The functional importance of this moleculehas been demonstrated by the study of LAT-deficient cell lines and LAT-deficient mice. Two other recently identified adaptor proteins, TRIM (T cell receptor interacting molecule) and SIT (SHP2-interacting transmembrane adaptor protein), which constitutively associate with several surface molecules,bind to PI3K and SHP2, respectively, after T cell activation and might also function in the TCR signalling pathway.

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Documento generato il 09/07/20 alle ore 00:53:08