Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Coeliac disease and Down syndrome: Associations not due to genetic linkageon chromosome 21
Autore:
Morris, MA; Yiannakou, JY; King, AL; Brett, PM; Biagi, F; Vaughan, R; Curtis, D; Ciclitira, PJ;
Indirizzi:
St Thomas Hosp, Rayne Inst, Gastroenterol Unit GKT, London SE1 7EH, England St Thomas Hosp London England SE1 7EH Unit GKT, London SE1 7EH, England Eastman Dent Inst UCL, Dept Periodontol, London, England Eastman Dent InstUCL London England Dept Periodontol, London, England Guys Hosp, Tissue Typing Lab, London SE1 9RT, England Guys Hosp London England SE1 9RT sue Typing Lab, London SE1 9RT, England St Bartholomews & Royal London Sch Med & Dent, Dept Psychol Med, London, England St Bartholomews & Royal London Sch Med & Dent London England n, England
Titolo Testata:
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
fascicolo: 2, volume: 35, anno: 2000,
pagine: 177 - 180
SICI:
0036-5521(200002)35:2<177:CDADSA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHILDHOOD CELIAC-DISEASE; DIABETES-MELLITUS; INCREASING INCIDENCE; ENDOMYSIAL ANTIBODY; ANTIGLIADIN; PREVALENCE; GLUTEN;
Keywords:
coeliac disease; Down syndrome; genetics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Ciclitira, PJ St Thomas Hosp, Rayne Inst, Gastroenterol Unit GKT, London SE1 7EH, England St Thomas Hosp London England SE1 7EH don SE1 7EH, England
Citazione:
M.A. Morris et al., "Coeliac disease and Down syndrome: Associations not due to genetic linkageon chromosome 21", SC J GASTR, 35(2), 2000, pp. 177-180

Abstract

Background: Individuals with Down syndrome have an increased prevalence ofcoeliac disease (CD). The HLA region accounts for only 30% of the heritability of CD, and segregation analyses have suggested the involvement of at least one other non-HLA gene. Distribution of known HLA susceptibility typesin Down syndrome and normal populations are similar and do not explain thedifference in disease frequency. This study tests the hypothesis that the association between these disorders is due to a susceptibility gene for coeliac disease being present on chromosome 21. Methods: We studied 21 families multiply affected with CD, none of whom had Down syndrome. The typing information of six microsatellite markers across chromosome 21 was used to test Linkage. Results: Negative results from lod score and model-free Linkage analysis were obtained, providing no support for genetic linkage of coeliacdisease to chromosome 21 in this population. Conclusions: The high prevalence of coeliac disease in Down syndrome is not due to an increased copy number of a polymorphic susceptibility gene on chromosome 21.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 10:55:33