Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Antigen-induced airway inflammation and hyper-responsiveness does not enhance airway responses to a subsequent antigen challenge in rats
Autore:
Laberge, S; Rossi, P; Yang, XX; Martin, JG;
Indirizzi:
McGill Univ, Royal Victoria Hosp, Meakins Christie Labs, Montreal, PQ H3A 1A1, Canada McGill Univ Montreal PQ Canada H3A 1A1 Labs, Montreal, PQ H3A 1A1, Canada Resp Hlth Network Ctr Excellence, Montreal, PQ, Canada Resp Hlth Network Ctr Excellence Montreal PQ Canada Montreal, PQ, Canada
Titolo Testata:
RESPIRATORY MEDICINE
fascicolo: 1, volume: 94, anno: 2000,
pagine: 44 - 50
SICI:
0954-6111(200001)94:1<44:AAIAHD>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATE ASTHMATIC RESPONSES; BROWN-NORWAY RATS; ALLERGEN CHALLENGE; BRONCHIAL RESPONSIVENESS; BRONCHOALVEOLAR LAVAGE; LYMPHOCYTES-T; HOUSE-DUST; EOSINOPHILS; IDENTIFICATION; MECHANISM;
Keywords:
Brown Norway; early response; eosinophils; late allergic response; ovalbumin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Martin, JG McGill Univ, Meakins Christie Labs, 3626 St Urbain St, Montreal, PQ H2X 2P2, Canada McGill Univ 3626 St Urbain St Montreal PQ Canada H2X 2P2 Canada
Citazione:
S. Laberge et al., "Antigen-induced airway inflammation and hyper-responsiveness does not enhance airway responses to a subsequent antigen challenge in rats", RESP MED, 94(1), 2000, pp. 44-50

Abstract

Brown-Norway (BN) rats develop airway hyper-responsiveness and lung eosinophilia 18-24 h after ovalbumin (OA) challenge. We hypothesized therefore that allergen-induced airway inflammation would further enhance airway responses to a subsequent antigen challenge. Animals were sensitized to both OA and bovine serum albumin (BSA) and, 14 days later, challenged by aerosols with both antigens 24 h apart. Measurements of pulmonary resistance (R-L) were made for 8 h after the second antigen challenge and bronchoalveolar lavage (BAL) was performed. Animals were divided into three groups and received two challenges as follows: saline-BSA (n=9), OA-saline (n=8) and OA-BSA (n=10). Sensitization was confirmed by measurements of specific OA-IgE and BSA-IgE. Early responses [determined as the highest value of R-L within the first 30 min after the challenge] were absent in all stud; groups. The late responses [determined from the area under the R-L versus time curve from 120to 480 min after the challenge] were significantly greater in animals challenged with BSA (15.16+3.86) compared to saline (3.76 +/- 4.09; P < 0.05). However previous exposure to OA did not further increase the late response in animals subsequently challenged with BSA (20.11 +/- 3.67) despite enhanced airway responsiveness to LTD4 at this time point. BAL eosinophils and lymphocytes were significantly increased following BSA challenge in previously OA-challenged animals, compared to numbers retrieved from animals previously exposed to saline (P < 0.05). These data indicate that previous exposure to OA did not further increase the LR to a second antigen challenge despite substantial increases in airway inflammatory cells and airway hyper-responsiveness to LTD4.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/02/20 alle ore 11:37:10