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Titolo:
Regulated exocytosis in immune function: are SNARE-proteins involved?
Autore:
Shukla, A; Berglund, L; Nielsen, LP; Nielsen, S; Hoffmann, HJ; Dahl, R;
Indirizzi:
Aarhus Univ Hosp, Dept Resp Dis, DK-8000 Aarhus, Denmark Aarhus Univ HospAarhus Denmark DK-8000 esp Dis, DK-8000 Aarhus, Denmark Aarhus Univ, Prot Chem Lab, DK-8000 Aarhus, Denmark Aarhus Univ Aarhus Denmark DK-8000 rot Chem Lab, DK-8000 Aarhus, Denmark Inst Anat Aarhus, Dept Cell Biol, DK-8000 Aarhus, Denmark Inst Anat Aarhus Aarhus Denmark DK-8000 ll Biol, DK-8000 Aarhus, Denmark
Titolo Testata:
RESPIRATORY MEDICINE
fascicolo: 1, volume: 94, anno: 2000,
pagine: 10 - 17
SICI:
0954-6111(200001)94:1<10:REIIFA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSITIVE FUSION PROTEIN; SYNAPTIC VESICLES; MAST-CELLS; SUBCELLULAR-LOCALIZATION; BINDING PROTEIN; MEMBRANE-FUSION; NEUROTRANSMITTER RELEASE; VESICULAR TRANSPORT; HUMAN NEUTROPHILS; SYNTAXIN-BINDING;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Shukla, A Aarhus Univ Hosp, Dept Resp Dis, DK-8000 Aarhus C, Denmark Aarhus Univ Hosp Aarhus Denmark C s, DK-8000 Aarhus C, Denmark
Citazione:
A. Shukla et al., "Regulated exocytosis in immune function: are SNARE-proteins involved?", RESP MED, 94(1), 2000, pp. 10-17

Abstract

Inflammation is an important feature in the pathogenesis of most chronic lung diseases. It is characterized by tissue infiltration with various inflammatory cells, including eosinophils, mast cells, basophils, macrophages, neutrophils, T- and B-lymphocytes and dendritic cells (1). In the tissue granulocytes release their toxic granule proteins after being. stimulated by soluble mediators released by other inflammatory cells (2). Therefore, it isimportant to characterize the intracellular mechanisms regulating the transport of the granule contents in inflammatroy cells. Intracellular vesicle-traffic in mammalian cells is mediated by transport vesicles that emerge from donor compartments and are specifically targeted to acceptor compartments where they deliver their contents after membrane fusion (3). This traffic leads to three types of fusion: vesicle-intracellular membranes, vesicle-vesicle or visicle-plasma membrane. The process leading to fusion of vesicle-plasma membrane is called exocytosis, and it delivers proteins to the cell surface (receptors e.g. CD11b, CD18) and exports soluble molecules (mediators e.g. ECP) from the cell. A number of key proteins involved in regulated exocytosis have been identified from inflammatory cells. This review is a brief summary of these proteins and it includes recent results from studies on regulated exocytosis in inflammatory cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/01/21 alle ore 22:36:23