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Titolo:
Effects of 2 weeks of treatment with fluticasone propionate 100 mcg b.d. by comparison with zafirlukast 20 mg b.d. on bronchial hyper-responsiveness in patients with mild to moderate asthma
Autore:
Westbroek, J; Pasma, HR;
Indirizzi:
Tjongerschans Algemeen Ziekerhuis, NL-8441 PM Heerenveen, Netherlands Tjongerschans Algemeen Ziekerhuis Heerenveen Netherlands NL-8441 PM ands MCL, Leeuwaden, Netherlands MCL Leeuwaden NetherlandsMCL, Leeuwaden, Netherlands
Titolo Testata:
RESPIRATORY MEDICINE
fascicolo: 2, volume: 94, anno: 2000,
pagine: 112 - 118
SICI:
0954-6111(200002)94:2<112:EO2WOT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEUKOTRIENE-RECEPTOR ANTAGONIST; BECLOMETHASONE DIPROPIONATE; AIRWAY HYPERRESPONSIVENESS; INDUCED BRONCHOCONSTRICTION; CLINICAL-EXPERIENCE; BUDESONIDE; HISTAMINE; EFFICACY; ALLERGEN; EXCRETION;
Keywords:
bronchial hyper-responsiveness; fluticasone propionate; zafirlukast; asthma; histamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Westbroek, J Tjongerschans Algemeen Ziekerhuis, Thialfweg 44, NL-8441 PM Heerenveen, Netherlands Tjongerschans Algemeen Ziekerhuis Thialfweg 44 Heerenveen Netherlands NL-8441 PM
Citazione:
J. Westbroek e H.R. Pasma, "Effects of 2 weeks of treatment with fluticasone propionate 100 mcg b.d. by comparison with zafirlukast 20 mg b.d. on bronchial hyper-responsiveness in patients with mild to moderate asthma", RESP MED, 94(2), 2000, pp. 112-118

Abstract

This study was designed to compare the effects of low-dose inhaled fluticasone propionate (100 meg twice daily) with those of the leukotriene antagonist, zafirlukast (20 mg twice daily), on bronchial hyper-responsiveness. The study recruited 30 patients (nine men, 21 women; mean age 45 years) with forced expiratory volume in 1 sec (FEV1) >50% and airway reversibility to salbutamol greater than or equal to 15%. This was a single centre? double-blind, double-dummy crossover study, composed of two successive 2-week treatment periods, each preceded by a 2-4 week single-blind placebo period. Following 2 weeks of treatment with fluticasone propionate and zafirlukast, the mean provocational concentration causing a 20% fan in FEV1 (PC20) histaminewas 1.61 mg ml(-1) (SD 2.34) and 0.99 mg ml(-1) (SD 1.74) respectively. Taking baseline differences into account, the difference between treatments was equivalent to 0.77 doubling doses of histamine (95% CI, 0.05-1.50; P=0.037). Morning peak flow values were significantly higher (17 1 min(-1); P=0.049) after treatment with fluticasone propionate during the second week of treatment. Both treatments were well tolerated. The results of this short-term study show that compared with zafirlukast, a low dose of fluticasone propionate offers greater clinical benefit and is more cost effective. (C) 2000 HARCOURT PUBLISHERS LTD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/02/20 alle ore 14:06:33