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Titolo:
Carbon monoxide and nitric oxide as coneurotransmitters in the enteric nervous system: Evidence from genomic deletion of biosynthetic enzymes
Autore:
Xue, L; Farrugia, G; Miller, SM; Ferris, CD; Snyder, SH; Szurszewski, JH;
Indirizzi:
Mayo Clin, Dept Physiol & Biophys, Div Gastroenterol & Hepatol, Rochester,MN 55905 USA Mayo Clin Rochester MN USA 55905 nterol & Hepatol, Rochester,MN 55905 USA Mayo Clin, Dept Med, Div Gastroenterol & Hepatol, Rochester, MN 55905 USA Mayo Clin Rochester MN USA 55905 terol & Hepatol, Rochester, MN 55905 USA Johns Hopkins Univ, Sch Med, Dept Neurosci, Div Gastroenterol, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 nterol, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Div Gastroenterol, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 nterol, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Div Gastroenterol,Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 enterol,Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Med, Div Gastroenterol, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 nterol, Baltimore, MD 21205 USA
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 4, volume: 97, anno: 2000,
pagine: 1851 - 1855
SICI:
0027-8424(20000215)97:4<1851:CMANOA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; HEME OXYGENASE; INTERSTITIAL-CELLS; NEURAL MESSENGER; MICE LACKING; DISEASE; LOCALIZATION; ACTIVATION; MECHANISMS; RELAXATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Farrugia, G Mayo Clin, Dept Physiol & Biophys, Div Gastroenterol & Hepatol, Rochester,MN 55905 USA Mayo Clin Rochester MN USA 55905 atol, Rochester,MN 55905 USA
Citazione:
L. Xue et al., "Carbon monoxide and nitric oxide as coneurotransmitters in the enteric nervous system: Evidence from genomic deletion of biosynthetic enzymes", P NAS US, 97(4), 2000, pp. 1851-1855

Abstract

Nitric oxide (NO) and carbon monoxide (CO) seem to be neurotransmitters inthe brain. The colocalization of their respective biosynthetic enzymes, neuronal NO synthase (nNOS) and heme oxygenase-2 (HO2), in enteric neurons and altered intestinal function in mice with genomic deletion of the enzymes (nNOS(Delta/Delta) and HO2(Delta/Delta)) suggest neurotransmitter roles forNO and CO in the enteric nervous system. We now establish that NO and CO are both neurotransmitters that interact as cotransmitters. Small intestinalsmooth muscle cells from nNOS(Delta/Delta) and HO2(Delta/Delta) mice are depolarized, with apparent additive effects in the double knockouts (HO2(Delta/Delta)nNOS(Delta/Delta)). Muscle relaxation and inhibitory neurotransmission are reduced in the mutant mice. In HO2(Delta/Delta) preparations, responses to electrical field stimulation are nearly abolished despite persistent nNOS expression, whereas exogenous CO restores normal responses, indicating that the NO system does not function in the absence of CO generation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 21:02:32