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Titolo:
Protective DNA vaccination against organ-specific autoimmunity is highly specific and discriminates between single amino acid substitutions in the peptide autoantigen
Autore:
Weissert, R; Lobell, A; de Graaf, KL; Eltayeb, SY; Andersson, R; Olsson, T; Wigzell, H;
Indirizzi:
Karolinska Hosp, CMM L8 04, Neuroimmunol Unit, S-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-17176 Unit, S-17176 Stockholm, Sweden Karolinska Inst, Ctr Microbiol & Tumor Biol, S-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17177 Biol, S-17177 Stockholm, Sweden Univ Tubingen, Dept Neurol, D-72076 Tubingen, Germany Univ Tubingen Tubingen Germany D-72076 Neurol, D-72076 Tubingen, Germany
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 4, volume: 97, anno: 2000,
pagine: 1689 - 1694
SICI:
0027-8424(20000215)97:4<1689:PDVAOA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYELIN BASIC-PROTEIN; T-CELL RECEPTOR; ORAL TOLERANCE; CLASS-I; ENCEPHALOMYELITIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Weissert, R Karolinska Hosp, CMM L8 04, Neuroimmunol Unit, S-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-17176 6 Stockholm, Sweden
Citazione:
R. Weissert et al., "Protective DNA vaccination against organ-specific autoimmunity is highly specific and discriminates between single amino acid substitutions in the peptide autoantigen", P NAS US, 97(4), 2000, pp. 1689-1694

Abstract

DNA vaccines that encode encephalitogenic sequences in tandem can protect from subsequent experimental autoimmune encephalomyelitis induced with the corresponding peptide. The mechanism for this protection and, in particular, if it is specific for the amino acid sequence encoding the vaccine are not known. We show here that a single amino acid exchange in position 79 fromserine (nonself) to threonine (self) in myelin basic protein peptide MBP68-85, which is a major encephalitogenic determinant for Lewis rats, dramatically alters the protection. Moreover, vaccines encoding the encephalitogenic sequence MBP68-85 do not protect against the second encephalitogenic sequence MBP89-101 in Lewis rats and vice versa, Thus, protective immunity conferred by DNA vaccination exquisitely discriminates between peptide target autoantigens. No bystander suppression was observed, The exact underlying mechanisms remain elusive because no simple correlation between impact on ex vivo responses and protection against disease were noted.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 09:09:48