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Titolo:
T-CELL POPULATION OF PRIMARY AND SECONDARY CUTANEOUS B-CELL LYMPHOMASDOES NOT EXPRESS THE CUTANEOUS LYMPHOCYTE-ASSOCIATED ANTIGEN (CLA)
Autore:
MARTI RM; HAUSMANN G; ESTRACH T; CID MC; PALOU J; HERRERO C; MASCARO JM;
Indirizzi:
HOSP CLIN BARCELONA,DEPT DERMATOL,VILLARROEL 170 BARCELONA 08036 SPAIN UNIV LLEIDA,DEPT DERMATOL LLEIDA 25198 SPAIN HOSP CLIN BARCELONA,DEPT INTERNAL MED BARCELONA 08036 SPAIN
Titolo Testata:
Archives of dermatological research
fascicolo: 6, volume: 289, anno: 1997,
pagine: 327 - 330
SICI:
0340-3696(1997)289:6<327:TPOPAS>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-SKIN; HECA-452; PHENOTYPE; DIFFERENTIATION; MIGRATION; CDW29+; CD4+;
Keywords:
CUTANEOUS B-CELL LYMPHOMA; T CELL; CLA; CD7;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
R.M. Marti et al., "T-CELL POPULATION OF PRIMARY AND SECONDARY CUTANEOUS B-CELL LYMPHOMASDOES NOT EXPRESS THE CUTANEOUS LYMPHOCYTE-ASSOCIATED ANTIGEN (CLA)", Archives of dermatological research, 289(6), 1997, pp. 327-330

Abstract

Primary cutaneous B-cell lymphomas (CBCL) are a group of malignant lymphomas with apparently distinct clinicopathological and immunophenotypical features, As in other B-cell lymphomas, the accompanying benign cell population in CBCL includes a variable number of T lymphocytes whose role is not well understood, In the present study we characterizedthe immunophenotype of these T cells and compared it with that of thereactive T-cell population in specific skin involvement by noncutaneous B-cell malignancies, Our results indicated that most T cells in both primary and secondary B-cell lymphomas were CLA(-) memory/effector helper T cells which differed from the currently known CLA(+) memory/effector helper T lymphocytes of the skin-associated lymphoid tissue (SALT) system, However, the endothelial CLA ligand, E-selectin, was expressed on dermal vessels, These results suggest that a B cell environment and/or a lack of epidermal involvement promote(s) the recruitment into the skin of a different, apparently less specific, subset of memoryhelper T cells from those seen in T-cell-mediated dermatoses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:39:16