Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Proarrhythmic effects of ibutilide in a canine model of pacing induced cardiomyopathy
Autore:
Hsieh, MH; Chen, YJ; Lee, SH; Ding, YA; Chang, MS; Chen, SA;
Indirizzi:
Vet Gen Hosp Taipei, Div Cardiol, Taipei, Taiwan Vet Gen Hosp Taipei Taipei Taiwan p Taipei, Div Cardiol, Taipei, Taiwan Natl Yang Ming Univ, Sch Med, Div Cardiol, Dept Med, Taipei 112, Taiwan Natl Yang Ming Univ Taipei Taiwan 112 diol, Dept Med, Taipei 112, Taiwan Wan Fang Hosp, Taipei Med Coll, Taipei, Taiwan Wan Fang Hosp Taipei Taiwan Fang Hosp, Taipei Med Coll, Taipei, Taiwan
Titolo Testata:
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
fascicolo: 2, volume: 23, anno: 2000,
pagine: 149 - 156
SICI:
0147-8389(200002)23:2<149:PEOIIA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
TORSADE-DE-POINTES; TACHYCARDIA-INDUCED CARDIOMYOPATHY; III ANTIARRHYTHMIC AGENT; QT INTERVAL DISPERSION; RECTIFIER K+-CURRENT; ATRIAL-FLUTTER; INTRAVENOUS IBUTILIDE; ACTION-POTENTIALS; HEART-FAILURE; SUDDEN-DEATH;
Keywords:
antiarrhythmic drugs; torsades de pointes; cardiomyopathy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Chen, SA Vet Gen Hosp Taipei, Div Cardiol, 201 Sec 2,Shih Pai Rd, Taipei, Taiwan Vet Gen Hosp Taipei 201 Sec 2,Shih Pai Rd Taipei Taiwan Taiwan
Citazione:
M.H. Hsieh et al., "Proarrhythmic effects of ibutilide in a canine model of pacing induced cardiomyopathy", PACE, 23(2), 2000, pp. 149-156

Abstract

The authors developed a canine model of pacing induced cardiomyopathy to study the possible mechanisms of ibutilide induced torsades de pointes (TP) in heart failure. Thirteen dogs received intravenous ibutilide after acute AV block for 60 minutes, and after implantation of a VVI pacemaker, r;with a rate of 270 beats/min for 2-3 weeks. Twelve-lead ECG and right and left ventricle monophasic action potentials were recorded at different right ventricle pacing cycle lengths from 600 ms to 1200 ms during the study. The results showed ibutilide could significantly prolong ventricular repolarization and increase the dispersion in a dose dependent and reverse use dependentmanner. Furthermore, after ibutilide administration, cardiomyopathic dogs had a greater dispersion of ventricular repolarization, and also had higherincidences of early afterdepolarizations and spontaneous or pacing inducedTP than acute AV block dogs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:47:53