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Titolo:
Role of TRAF2/GCK in melanoma sensitivity to UV-induced apoptosis
Autore:
Ivanov, VN; Kehrl, JH; Ronai, Z;
Indirizzi:
CUNY Mt Sinai Sch Med, Ruttenberg Canc Ctr, New York, NY 10029 USA CUNY MtSinai Sch Med New York NY USA 10029 c Ctr, New York, NY 10029 USA NIH, Immunoregulat Lab, Bethesda, MD 20892 USA NIH Bethesda MD USA 20892NIH, Immunoregulat Lab, Bethesda, MD 20892 USA
Titolo Testata:
ONCOGENE
fascicolo: 7, volume: 19, anno: 2000,
pagine: 933 - 942
SICI:
0950-9232(20000217)19:7<933:ROTIMS>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
NF-KAPPA-B; RECEPTOR-ASSOCIATED FACTOR-2; FAS LIGAND EXPRESSION; FACTOR TNF RECEPTOR-1; TERMINAL KINASE; SIGNAL-TRANSDUCTION; INDUCED ACTIVATION; CELL-DEATH; T-CELLS; PATHWAYS;
Keywords:
TRAF2; GCK; NF-kappa B; melanoma; apoptosis; UV-irradiation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Ronai, Z CUNY Mt Sinai Sch Med, Ruttenberg Canc Ctr, 1425 Madison Ave,Room15-20, New York, NY 10029 USA CUNY Mt Sinai Sch Med 1425 Madison Ave,Room 15-20 New York NY USA 10029
Citazione:
V.N. Ivanov et al., "Role of TRAF2/GCK in melanoma sensitivity to UV-induced apoptosis", ONCOGENE, 19(7), 2000, pp. 933-942

Abstract

Radiation resistance is a hallmark of human melanoma, and yet mechanisms underlying this resistance are not well understood. We recently established the role of ATF2 in this process, suggesting that stress kinases, which contribute to regulation of ATF2 stability and activity, play an important role in the acquisition of such resistance. Here we demonstrate that changes in the expression and respective activities of TRAF2/GCK occur during melanoma development and regulate its sensitivity to UV-induced apoptosis, Comparing early- and late-stage melanoma cells revealed low expression of TRAF2 and GCK in early-stage melanoma, which coincided with poor resistance to UV-induced, TNF-mediated apoptosis; forced expression of GCK alone or in combination with TRAF2 efficiently increased JNK and NF-kappa B activities, which coincided with increased protection against apoptosis, Conversely, forcedexpression of the dominant negative form of TRAF2 or GCK in late-stage melanoma cells reduced NF-kappa B activity and decreased Fas expression, resulting in a lower degree of UV-induced, Fas-mediated cell death. Our results illustrate a mechanism in which protection from, or promotion of, UV-induced melanoma cell death depends on the nature of the apoptotic cascade (TNF or Fas) and on the availability of TRAF2/GCK, whose expression increases during melanoma progression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:42:06