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Titolo:
The adenovirus type 5 E1B-55K oncoprotein is a highly active shuttle protein and shuttling is independent of E4orf6, p53 and Mdm2
Autore:
Kratzer, F; Rosorius, O; Heger, P; Hirschmann, N; Dobner, T; Hauber, J; Stauber, RH;
Indirizzi:
Univ Erlangen Nurnberg, Inst Clin & Mol Virol, D-91054 Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany D-91054 -91054 Erlangen, Germany Univ Regensburg, Inst Med Mikrobiol & Hyg, D-93053 Regensburg, Germany Univ Regensburg Regensburg Germany D-93053 , D-93053 Regensburg, Germany
Titolo Testata:
ONCOGENE
fascicolo: 7, volume: 19, anno: 2000,
pagine: 850 - 857
SICI:
0950-9232(20000217)19:7<850:TAT5EO>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
REGION-4 34-KILODALTON PROTEIN; NUCLEAR EXPORT; 55-KILODALTON PROTEIN; MESSENGER-RNAS; INFECTED-CELLS; TRANSFORMED-CELLS; TUMOR-ANTIGEN; LIVING CELLS; REV PROTEIN; SEQUENCE;
Keywords:
adenovirus; nucleo-cytoplasmic transport; oncoproteins; GFP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Stauber, RH Univ Erlangen Nurnberg, Inst Clin & Mol Virol, Schlossgarten 4, D-91054 Erlangen, Germany Univ Erlangen Nurnberg Schlossgarten 4 Erlangen Germany D-91054
Citazione:
F. Kratzer et al., "The adenovirus type 5 E1B-55K oncoprotein is a highly active shuttle protein and shuttling is independent of E4orf6, p53 and Mdm2", ONCOGENE, 19(7), 2000, pp. 850-857

Abstract

The E1B-55K and E4orf6 oncoproteins of adenovirus type 5 are involved in the export of viral mRNAs, Previously, it cr as suggested that a complex composed of E1B-55K and E4orf6 serves as a nucleocytoplasmic transporter for viral mRNAs in which the E4orf6 protein directs both nuclear import and export, We now demonstrate that the E1B-55K protein itself shuttles efficientlyin the absence of E4orf6, In addition, E1B-55K trafficking was independentof the defined shuttle proteins Mdm2 or p53, which interacts with E1B-55K,The identified N-terminal E1B-55K leucine-rich nuclear-export signal (NES)conferred rapid nuclear export even in a heterologous system in contrast to the postulated E4orf6NES, Interestingly, although shuttling was blocked by inhibitors of the CRM1 mediated export pathway, E1B-55K inhibited neitherthe activity nor the trafficking of the retroviral shuttle proteins HIV-1 Rev and HTLV-1 Rex, In contrast, Rev or Rex blocked the nuclear export of E1B-55K, most likely by competing for essential export factors, Our results provide new insights into the regulation of the adenovirus mRNA export system and the processes of adenovirus mediated transformation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 22:33:36