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Titolo:
Opioid modulation of magnocellular neurosecretory cell activity
Autore:
Brown, CH; Russell, JA; Leng, G;
Indirizzi:
Univ Edinburgh, Dept Biomed Sci, Neuroendocrinol Lab, Edinburgh EH8 9XD, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH8 9XD Midlothian, Scotland
Titolo Testata:
NEUROSCIENCE RESEARCH
fascicolo: 2, volume: 36, anno: 2000,
pagine: 97 - 120
SICI:
0168-0102(200002)36:2<97:OMOMNC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT SUPRAOPTIC NUCLEUS; MILK-EJECTION REFLEX; VASOPRESSIN-CONTAINING NEURONS; PRECIPITATED MORPHINE-WITHDRAWAL; FOS-LIKE IMMUNOREACTIVITY; KAPPA-OPIATE RECEPTORS; OXYTOCIN NEURONS; PARAVENTRICULAR NUCLEUS; ANESTHETIZED RATS; MESSENGER-RNA;
Keywords:
dependence; dynorphins; morphine; opioid receptors; oxytocin; paraventricular nucleus; supraoptic nucleus; vasopressin;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
259
Recensione:
Indirizzi per estratti:
Indirizzo: Brown, CH Univ Edinburgh, Dept Biomed Sci, Neuroendocrinol Lab, Hugh Robson Bldg, Edinburgh EH8 9XD, Midlothian, Scotland Univ Edinburgh Hugh Robson Bldg Edinburgh Midlothian Scotland EH8 9XD
Citazione:
C.H. Brown et al., "Opioid modulation of magnocellular neurosecretory cell activity", NEUROSCI RE, 36(2), 2000, pp. 97-120

Abstract

Magnocellular neurosecretory cells of the hypothalamic supraoptic and paraventricular nuclei secrete the hormones. oxytocin and vasopressin, into thesystemic circulation from the posterior pituitary gland. Oxytocin is important for parturition and is essential for lactation. Vasopressin regulates body fluid homeostasis. The secretion of these hormones is altered in response to peripheral stimuli that are conveyed via projections from other parts of the brain. Endogenous opioid peptide systems interact with the magnocellular neurosecretory system at several levels to restrain the basal secretion of these hormones as well as their secretory responses to various physiological stimuli. The inhibition of basal secretion can occur at the level of the neurosecretory terminals where endogenous opioids inhibit the release of oxytocin, and at the cell bodies of magnocellular cells to modulate the activity pattern of vasopressin cells. The responses of the magnocellularneurosecretory system to physiological stimuli are also regulated by thesemechanisms but in addition probably also by pre-synaptic inhibition of afferent inputs to magnocellular cells as well as direct effects on the cell bodies of efferent input cells to modulate their activity. Here, Lye review the mechanisms and functional consequences of opioid interactions with oxytocin and vasopressin cells. (C) 2000 Elsevier Science Ireland Ltd. AU rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 11:18:50