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Titolo:
Dynorphin A-(1-13) and (2-13) improve beta-amyloid peptide-induced amnesiain mice
Autore:
Hiramatsu, M; Inoue, K; Kameyama, T;
Indirizzi:
Meijo Univ, Fac Pharmaceut Sci, Dept Chem Pharmacol, Tempaku Ku, Nagoya, Aichi 4688503, Japan Meijo Univ Nagoya Aichi Japan 4688503 ku Ku, Nagoya, Aichi 4688503, Japan
Titolo Testata:
NEUROREPORT
fascicolo: 3, volume: 11, anno: 2000,
pagine: 431 - 435
SICI:
0959-4965(20000228)11:3<431:DAA(IB>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED DELAYED AMNESIA; NONOPIOID MECHANISM; INDUCED IMPAIRMENT; CEREBRAL-ISCHEMIA; OPIOID RECEPTOR; NMDA RECEPTOR; MEMORY; RATS; CURRENTS; NEURONS;
Keywords:
alternation behavior; beta-amyloid peptide; cholinergic neuronal system; dynorphin A-(1-13); dynorphin A-(2-13); kappa opioid receptor; nor-binaltorphimine dihydrochloride; non-opioid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Hiramatsu, M Meijo Univ, Fac Pharmaceut Sci, Dept Chem Pharmacol, Tempaku Ku, 150 Yagotoyama, Nagoya, Aichi 4688503, Japan Meijo Univ 150 Yagotoyama Nagoya Aichi Japan 4688503 3, Japan
Citazione:
M. Hiramatsu et al., "Dynorphin A-(1-13) and (2-13) improve beta-amyloid peptide-induced amnesiain mice", NEUROREPORT, 11(3), 2000, pp. 431-435

Abstract

The anti-amnesic effects of dynorphins on beta-amyloid peptide-(25-35)-induced impairment of learning and/or memory in mice were investigated using aY-maze task and a passive avoidance test. Administration of beta-amyloid peptide-(25-35) (beta AP(25-35); 8.2 nmol, i.c.v.) 7 and 14 days before behavioral tests induced a decrease in both alternation behavior and latency inpassive avoidance tests. Dynorphin A-(1-13) and A-(2-13) (0.5 and/or 1.5 nmol, i.c.v.) 30 min before behavioral tests improved the beta-amyloid peptide-(25-35)-induced impairment of alternation performance and shortened the step-down latency. Nor-binaltor-phimmine (4.9 nmol, i.c.v.) partially blocked the effects of dynorphin A-(1-13), but not A-(2-13). These results indicate that dynorphin A-(1-13) and A-(2-13) improve amnesia induced by beta AP-(25-35) via not only kappa opioid receptors, but also by non-opioid mechanisms. NeuroReport 11:431-435 (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 23:43:53