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Titolo:
Interactions between distinct GABA(A) circuits in hippocampus
Autore:
Banks, MI; White, JA; Pearce, RA;
Indirizzi:
Univ Wisconsin, Dept Anesthesiol, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 pt Anesthesiol, Madison, WI 53706 USA Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA Boston Univ Boston MAUSA 02215 v, Dept Biomed Engn, Boston, MA 02215 USA
Titolo Testata:
NEURON
fascicolo: 2, volume: 25, anno: 2000,
pagine: 449 - 457
SICI:
0896-6273(200002)25:2<449:IBDGCI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; PATCH-CLAMP RECORDINGS; CORTEX COMBINED SLICE; PYRAMIDAL CELLS; RAT HIPPOCAMPUS; ENTORHINAL CORTEX; THETA-RHYTHM; IN-VIVO; GAMMA-OSCILLATION; BEHAVING RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Pearce, RA Univ Wisconsin, Dept Anesthesiol, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 iol, Madison, WI 53706 USA
Citazione:
M.I. Banks et al., "Interactions between distinct GABA(A) circuits in hippocampus", NEURON, 25(2), 2000, pp. 449-457

Abstract

Synchronous activity among synaptically connected interneurons is thought to organize temporal patterns such as gamma and theta rhythms in cortical circuits. Interactions between distinct interneuron circuits may underlie more complex patterns, such as nested rhythms. Here, we demonstrate such an interaction between two groups of CA1 interneurons, GAB(A,) (slow) and GABA(A,fast) cells, that may contribute to theta and gamma rhythms, respectively. Stratum lacunosum-moleculare (SL-M) stimuli that activate GABA(A,slow) inhibitory postsynaptic currents (IPSCs) in pyramidal cells simultaneously depress the rate and amplitude of spontaneous GABA(A,fast) IPSCs for several hundred milliseconds. This suppression has a similar pharmacological profile to GABA(A,slow) IPSCs, and SL-M stimuli elicit GABA(A,slow) IPSCs in interneurons. We conclude that GABA(A,slow) cells inhibit both pyramidal cells and GABA(A,fast) interneurons and postulate that this interaction contributes to nested theta/gamma rhythms in hippocampus.

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Documento generato il 04/04/20 alle ore 07:54:42