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Titolo:
Maturation and maintenance of the neuromuscular synapse: Genetic evidence for roles of the dystrophin-glycoprotein complex
Autore:
Grady, RM; Zhou, H; Cunningham, JM; Henry, MD; Campbell, KP; Sanes, JR;
Indirizzi:
Washington Univ, Sch Med, Dept Anat & Neurobiol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 & Neurobiol, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Dept Pediat, St Louis, MO 63110 USA Univ Iowa, Coll Med, Dept Physiol & Biophys, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 ysiol & Biophys, Iowa City, IA 52242 USA Univ Iowa, Coll Med, Dept Neurol, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 ed, Dept Neurol, Iowa City, IA 52242 USA
Titolo Testata:
NEURON
fascicolo: 2, volume: 25, anno: 2000,
pagine: 279 - 293
SICI:
0896-6273(200002)25:2<279:MAMOTN>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACETYLCHOLINE-RECEPTOR AGGREGATION; DUCHENNE MUSCULAR-DYSTROPHY; UTROPHIN-DEFICIENT MICE; TORPEDO ELECTRIC ORGAN; SKELETAL-MUSCLE; ALPHA-DYSTROGLYCAN; AGRIN RECEPTOR; MUTANT MICE; DYSTROBREVIN ISOFORMS; BETA-DYSTROBREVIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Sanes, JR Washington Univ, Sch Med, Dept Anat & Neurobiol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 l, St Louis, MO 63110 USA
Citazione:
R.M. Grady et al., "Maturation and maintenance of the neuromuscular synapse: Genetic evidence for roles of the dystrophin-glycoprotein complex", NEURON, 25(2), 2000, pp. 279-293

Abstract

The dystrophin-glycoprotein complex (DGC) links the cytoskeleton of musclefibers to their extracellular matrix. Using knockout mice, we show that a cytoplasmic DGC component, alpha-dystrobrevin (alpha-DB), is dispensable for formation of the neuromuscular junction (NMJ) but required for maturationof its postsynaptic apparatus. We also analyzed double and triple mutants lacking other cytoskeletal DGC components (utrophin and dystrophin) and myotubes lacking a alpha-DB or a transmembrane DGC component (dystroglycan). Our results suggest that alpha-DB acts via its linkage to the DGC to enhancethe stability of postsynaptic specializations following their DGC-independent formation; dystroglycan may play additional roles in assembling synaptic basal lamina. Together, these results demonstrate involvement of distinctprotein complexes in the formation and maintenance of the synapse and implicate the DGC in the latter process.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 15:26:48