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Titolo:
Activation of striatal group II metabotropic glutamate receptors has a differential effect on dopamine-D-1 and -D-2 receptor antagonist-induced hypokinesia in the rat
Autore:
Kronthaler, UO; Schmidt, WJ;
Indirizzi:
Scantox AS, DK-4623 Lille Skensved, Denmark Scantox AS Lille Skensved Denmark DK-4623 K-4623 Lille Skensved, Denmark Univ Tubingen, Dept Neuropharmacol, D-72074 Tubingen, Germany Univ Tubingen Tubingen Germany D-72074 rmacol, D-72074 Tubingen, Germany
Titolo Testata:
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
fascicolo: 3, volume: 361, anno: 2000,
pagine: 289 - 297
SICI:
0028-1298(200003)361:3<289:AOSGIM>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
AGONIST-INDUCED ROTATION; METHYL-D-ASPARTATE; BASAL GANGLIA; IN-VIVO; PERFORANT PATH; SPINAL-CORD; DCG-IV; SCHIZOPHRENIA; NEURONS; CATALEPSY;
Keywords:
schizophrenia; motor behaviour; amino acids;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Kronthaler, UO Scantox AS, Hestehavevej 36A, DK-4623 Lille Skensved, Denmark Scantox AS Hestehavevej 36A Lille Skensved Denmark DK-4623
Citazione:
U.O. Kronthaler e W.J. Schmidt, "Activation of striatal group II metabotropic glutamate receptors has a differential effect on dopamine-D-1 and -D-2 receptor antagonist-induced hypokinesia in the rat", N-S ARCH PH, 361(3), 2000, pp. 289-297

Abstract

Motor function of group II metabotropic glutamate receptors was investigated by quantifying motor effects of bilateral infusions of the preferential group II metabotropic glutamate receptor agonist (2S,3S,4S)-alpha-carboxycyclopropyl-glycine (15, 30, 60 nmol/0.5 mu l) into the striatum of consciousrats. (2S,3S,4S)-alpha-carboxycyclopropyl-glycine reduced spontaneous sniffing activity in an experimental chamber, but did not affect spontaneous locomotor (line crossings) or exploratory behaviour (rearings, hole visits) in an open field equipped with a hole-board. Intrastriatal infusion of the selective group III metabotropic glutamate receptor agonist L-2-amino-4-phosphobutyric acid (15, 30, 60, 120 nmol/0.5 mu l) did not influence spontaneous motor behaviour. Intrastriatal infusion of (2S,3S,3S)-alpha-carboxycyclopropylglycine (15 nmol/0.5 mu l and 30 nmol/0.5 mu l) further depressed spontaneous motor behaviour in rats pretreated with the dopamine-D-1 receptor antagonist (-)-trans-6,7,7 a, 8,9, 13b-hexahydro-3-chloro-2-hydroxy-N-methyl-5H-benzo[d]naphtho-(2,1-b)azepine, but not if rats were pretreated with the preferential dopamine-D-2 receptor antagonist haloperidol. It appears likely that the depression of spontaneous motor behaviour evoked by the preferential group II, agonist (2S,3S,4S)-alpha-carboxycyclopropyl-glycine is mediated by activation of group II metabotropic glutamate receptors, since activation of group I metabotropic glutamate receptors has beenshown to stimulate motor behav lour, and activation of group III metabotropic glutamate receptors had no effect, as shown in this study. Therefore, it is reasonable to speculate that the striatum may contribute to the motor-depressant effects of systemically applied group II metabotropic glutamate receptor agonists, as reported by us recently. The present findings furthersuggest that a functional dopamine-D-1 antagonism contributes to the motoreffects of group II metabotropic glutamate receptor agonists.

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Documento generato il 08/04/20 alle ore 23:20:45