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Titolo:
Cocaine abusers show a blunted response to alcohol intoxication in limbic brain regions
Autore:
Volkow, ND; Wang, GJ; Fowler, JS; Franceschi, D; Thanos, PK; Wong, C; Gatley, SJ; Ding, YS; Molina, P; Schlyer, D; Alexoff, D; Hitzemann, R; Pappas, N;
Indirizzi:
Brookhaven Natl Lab, Dept Med, Upton, NY 11973 USA Brookhaven Natl Lab Upton NY USA 11973 Lab, Dept Med, Upton, NY 11973 USA SUNY Stony Brook, Dept Psychiat, Stony Brook, NY 11794 USA SUNY Stony Brook Stony Brook NY USA 11794 hiat, Stony Brook, NY 11794 USA Louisiana State Univ, Dept Physiol, New Orleans, LA 70112 USA Louisiana State Univ New Orleans LA USA 70112 , New Orleans, LA 70112 USA
Titolo Testata:
LIFE SCIENCES
fascicolo: 12, volume: 66, anno: 2000,
pagine: PL161 - PL167
SICI:
0024-3205(20000211)66:12<PL161:CASABR>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ETHANOL; METABOLISM; BENZODIAZEPINES; RAT;
Keywords:
drug addiction; reward; brain glucose metabolism; positron emission tomography; neurotoxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Volkow, ND Brookhaven Natl Lab, Dept Med, Upton, NY 11973 USA Brookhaven Natl Lab Upton NY USA 11973 ed, Upton, NY 11973 USA
Citazione:
N.D. Volkow et al., "Cocaine abusers show a blunted response to alcohol intoxication in limbic brain regions", LIFE SCI, 66(12), 2000, pp. PL161-PL167

Abstract

Cocaine and alcohol are frequently used simultaneously and this combination is associated with enhanced toxicity. We recently showed that active:cocaine abusers have a markedly enhanced sensitivity to benzodiazepines. Because both benzodiazepines and alcohol facilitate GABAergic neurotransmission we questioned whether cocaine abusers would also have an enhanced sensitivity to alcohol that could contribute to the toxicity. In this study we compared the effects of alcohol (0.75 g/kg) on regional brain glucose metabolism between cocaine abusers (n=9) and controls (n=10) using PET and FDG. Alcohol significantly decreased whole brain metabolism and this effect was greater in controls (26+/-6%) than in abusers (17+/-10%) even though they had equivalent levels of alcohol in plasma. Analysis of the regional measures showed that cocaine abusers had a blunted response to alcohol in limbic regions, cingulate gyrus, medial frontal and orbitofrontal cortices, Conclusions: The blunted response to alcohol in cocaine abusers contrasts with their enhanced sensitivity to benzodiazepines suggesting that targets other than GABA-benzodiazepine receptors are involved in the blunted sensitivity to alcohol and that the toxicity from combined cocaine-alcohol use is not due to anenhanced sensitivity to alcohol in cocaine abusers. The blunted response to alcohol in limbic regions and in cortical regions connected to limbic areas could result from a decreased sensitivity of reward circuits in cocaine abusers. (C) 2000 Elsevier Science Inc.

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Documento generato il 19/01/20 alle ore 09:06:35