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Titolo:
Dizocilpine-induced neuropathological changes in rat retrosplenial cortex are reversed by subsequent clozapine treatment
Autore:
Hashimoto, K; Fujimura, M; Yamagami, K;
Indirizzi:
Yoshitomi Pharmaceut Ind Ltd, Tokyo Labs, Iruma, Saitama 3580026, Japan Yoshitomi Pharmaceut Ind Ltd Iruma Saitama Japan 3580026 a 3580026, Japan
Titolo Testata:
LIFE SCIENCES
fascicolo: 12, volume: 66, anno: 2000,
pagine: 1071 - 1078
SICI:
0024-3205(20000211)66:12<1071:DNCIRR>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIPSYCHOTIC-DRUGS; POSTERIOR CINGULATE; MESSENGER-RNA; PYRAMIDAL NEURONS; PHENCYCLIDINE; BRAIN; SCHIZOPHRENIA; INDUCTION; MK-801; ANTAGONIST;
Keywords:
NMDA receptor antagonist; neurotoxicity; clozapine; retrosplenial cortex; dizocilpine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Hashimoto, K Yoshitomi Pharmaceut Ind Ltd, Tokyo Labs, 7-25 Koyata 3 Chome, Iruma, Saitama 3580026, Japan Yoshitomi Pharmaceut Ind Ltd 7-25 Koyata 3 Chome Iruma Saitama Japan 3580026
Citazione:
K. Hashimoto et al., "Dizocilpine-induced neuropathological changes in rat retrosplenial cortex are reversed by subsequent clozapine treatment", LIFE SCI, 66(12), 2000, pp. 1071-1078

Abstract

In this study, we examined the effect of post-treatment with clozapine on the neuropathological changes in the rat retrosplenial cortex induced by the administration of non-competitive NMDA receptor antagonist dizocilpine (()-MK-801). The maximal increase in vacuolized: neurons, which are representative of neuropathology, was observed 4 hours: after a single injection ofdizocilpine (0.5 mg/kg s.c.), with a complete reversal of the neuropathology after 16-24 hours. The administration of clozapine (10 mg/kg, i.p.,) 4 hours after the administration of dizocilpine significantly decreased the number of vacuolized neurons in the retrosplenial cortex 6, 8 or 10 hours after administration of dizocilpine, compared to vehicle-treated animals. Furthermore, the administration of clozapine (5, 10 or 20 mg/kg i.p.) 4 hours after the administration of dizocilpine produced a significant decrease in the number of vacuolized neurons in the retrosplenial cortex in a dose-dependent manner when measure 6 hours post-dizocilpine. These results show that neuropathological changes in the rat retrosplenial cortex produced by dizocilpine can be attenuated by post-treatment with clozapine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 15:54:59