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Titolo:
Increased bone strontium levels in hemodialysis patients with osteomalacia
Autore:
DHaese, PC; Schrooten, I; Goodman, WG; Cabrera, WE; Lamberts, LV; Elseviers, MM; Couttenye, MM; De Broe, ME;
Indirizzi:
Univ Antwerp Hosp, Dept Nephrol Hypertens, B-2650 Edegem, Belgium Univ Antwerp Hosp Edegem Belgium B-2650 ypertens, B-2650 Edegem, Belgium Univ Calif Los Angeles, Med Ctr, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Fac Ciencias Med, Asuncion, Paraguay Fac Ciencias Med Asuncion ParaguayFac Ciencias Med, Asuncion, Paraguay
Titolo Testata:
KIDNEY INTERNATIONAL
fascicolo: 3, volume: 57, anno: 2000,
pagine: 1107 - 1114
SICI:
0085-2538(200003)57:3<1107:IBSLIH>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATOMIC-ABSORPTION SPECTROMETRY; INTESTINAL CALCIUM-ABSORPTION; ALKALINE-PHOSPHATASE; RENAL OSTEODYSTROPHY; DISEASE; ALUMINUM; SERUM; RATS; INHIBITION; DIALYSIS;
Keywords:
renal osteodystrophy; bone histology; mineralization; trace metal; dialysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: De Broe, ME Univ Antwerp Hosp, Dept Nephrol Hypertens, Wilrijkstr 10, B-2650 Edegem, Belgium Univ Antwerp Hosp Wilrijkstr 10 Edegem Belgium B-2650 Belgium
Citazione:
P.C. D'Haese et al., "Increased bone strontium levels in hemodialysis patients with osteomalacia", KIDNEY INT, 57(3), 2000, pp. 1107-1114

Abstract

Background. In this study, we report on the association between increased bone strontium levels and the presence of osteomalacia in end-stage renal failure patients treated by hemodialysis. Method's. We performed a histologic examination and determined the strontium content and strontium/calcium ratios in bone biopsies of 100 hemodialysis patients recruited from various centers all over the world. Aside from the bone strontium concentration, the bone aluminum content was assessed. Thebone zinc concentration, a nonrelevant element for bone toxicity, was alsomeasured. Results. Bone strontium levels and bone strontium/calcium ratios were increased in subjects with osteomalacia when compared with those with the othertypes of renal osteodystrophy. Bone strontium and bone calcium levels correlated with each other. The slope of the linear regression curve correlating these parameters was much steeper in the osteomalacic group (Y = 2.22X - 120) as compared with the other types of renal osteodystrophy (Y = 0.52X - 5.7). Within the group of patients with osteomalacia, bone strontium levelsalso significantly correlated with the bone aluminum content (r = 0.72, P = 0.018). No such correlation was found for the other types of renal osteodystrophy. The bone zinc concentration of subjects with normal renal function did not differ significantly from the values noted for the various types of renal osteodystrophy taken as separate groups, nor could increased bone zinc concentrations be associated with a particular bone lesion. Conclusions. Our data demonstrate an association between osteomalacia and increased bone strontium concentrations in dialysis patients. Further studies are warranted to establish whether strontium plays either a primary, secondary, or contributive role in the development of the latter type of renalosteodystrophy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 19:53:44