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Titolo:
Vagal innervation of the rat duodenum
Autore:
Zhang, XG; Renehan, WE; Fogel, R;
Indirizzi:
Henry Ford Hosp, Div Gastroenterol, Neurogastroenterol Lab, Detroit, MI 48202 USA Henry Ford Hosp Detroit MI USA 48202 roenterol Lab, Detroit, MI 48202 USA
Titolo Testata:
JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM
fascicolo: 1, volume: 79, anno: 2000,
pagine: 8 - 18
SICI:
0165-1838(20000214)79:1<8:VIOTRD>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL MOTOR NUCLEUS; ENTERIC NERVOUS-SYSTEM; SMALL-INTESTINE; VAGUS NERVE; AFFERENT-FIBERS; VISCEROTOPIC REPRESENTATION; SENSITIVE NEURONS; CERVICAL VAGUS; SOLITARY TRACT; BRAIN-STEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Fogel, R Henry Ford Hosp, Div Gastroenterol, Neurogastroenterol Lab, 2799 W Grand Blvd, Detroit, MI 48202 USA Henry Ford Hosp 2799 W Grand Blvd Detroit MI USA 48202 48202 USA
Citazione:
X.G. Zhang et al., "Vagal innervation of the rat duodenum", J AUTON NER, 79(1), 2000, pp. 8-18

Abstract

Electrophysiologic and anterograde tract tracing studies have demonstratedthat the vagus nerve innervates the duodenum. These studies, however, haveprovided little information regarding the finer anatomic topography withinthe vagal complex. In this study, the retrograde neuronal tracers WGA-HRP or DiI applied to the duodenum, were used to characterize the vagal afferent and efferent innervation of this portion of the gastrointestinal tract. This approach labeled a substantial number of meter neurons in both the medial and lateral columns of the dorsal motor nucleus of the vagus (DMNV). Vagal motor neurons innervating the duodenum were seen across the medial-lateral extent of the DMNV and between 600 mu m rostral to obex and 1600 mu m caudal to obex. The three branches of the vagus nerve contained efferent fibers to the duodenum. The gastric branch of the vagus nerve was the pathway that connected the majority of DMNV neurons with the duodenum. These neuronswere located in the medial and middle thirds of the DMNV. The celiac branch to the duodenum was composed of axons from the majority of lateral columnneurons but also contained axons from neurons in the medial column. The hepatic branch of the vagus nerve contained only a small number of cell axons. Some neurons were located medially whereas others were in the lateral third of the duodenum. Although central terminations of vagal primary afferents from the duodenum were not found in previous tract tracing studies, we observed a large number of terminals in the subpostremal/commissural region of the nucleus of the solitary tract. Similar to the motor fibers, most afferent fibers from the duodenum were located in the gastric branch of the vagus nerve, although the hepatic and celiac branches also contained afferent neurons. These results demonstrate that the vagal innervation of the duodenum is unique, being an amalgam of what would be expected following labelingof more proximal and distal portions of the GI tract. The uniqueness of the sensory and motor innervation to the duodenum has implications for hypotheses regarding the organization of vagovagal reflexes controlling gastrointestinal function. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:43:48