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Titolo:
Ventilatory and central neurochemical reorganisation of O-2 chemoreflex after carotid sinus nerve transection in rat
Autore:
Roux, JC; Peyronnet, J; Pascual, O; Dalmaz, Y; Pequignot, JM;
Indirizzi:
UMR CNRS 5578, Fac Med, Lab Physiol Regulat Metab Cellulaires & Mol, F-69373 Lyon 08, France UMR CNRS 5578 Lyon France 08 Cellulaires & Mol, F-69373 Lyon 08, France
Titolo Testata:
JOURNAL OF PHYSIOLOGY-LONDON
fascicolo: 3, volume: 522, anno: 2000,
pagine: 493 - 501
SICI:
0022-3751(20000201)522:3<493:VACNRO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
BODY-DENERVATED RATS; IN-VITRO RESPONSES; VENTROLATERAL MEDULLA; BRAIN-STEM; CHEMORECEPTOR FUNCTION; CENTRAL REORGANIZATION; AWAKE RAT; HYPOXIA; NEURONS; GLOSSOPHARYNGEAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Roux, JC UMR CNRS 5578, Fac Med, Lab Physiol Regulat Metab Cellulaires & Mol, 8 AveRockefeller, F-69373 Lyon 08, France UMR CNRS 5578 8 Ave Rockefeller Lyon France 08 3 Lyon 08, France
Citazione:
J.C. Roux et al., "Ventilatory and central neurochemical reorganisation of O-2 chemoreflex after carotid sinus nerve transection in rat", J PHYSL LON, 522(3), 2000, pp. 493-501

Abstract

1. The first step of this study was to determine the early time course andpattern of hypoxic ventilatory response (HVR) recovery following irreversible bilateral carotid sinus nerve transection (CSNT). The second step was to find out if HVR recovery was associated with changes in the neurochemicalactivity of the medullary catecholaminergic cell groups involved in the O-2 chemoreflex pathway.2. The breathing response to acute hypoxia (10% O-2) was measured in awakerats 2, 6, 10, 45 and 90 days after CSNT. In a control group of sham-operated rats, the ventilatory response to hypoxia was principally due to increased respiratory frequency. There was a large reduction in HVR in the CSNT compared to the sham-operated rats (-65%, 2 days after surgery). Within the weeks following denervation, the CSNT rats progressively recovered a HVR level similar to the sham-operated rats (-37% at 6 days, -27 % at 10 days, and no difference at 45 or 90 days). After recovery, the CSNT rats exhibited a higher tidal volume (+38 %) than the sham-operated rats in response to hypoxia, but not a complete recovery of respiratory frequency.3. Fifteen days after CSNT, in vivo tyrosine hydroxylase (TH) activity haddecreased in caudal A(2)C(2) (-35%) and A(6) cells (-35%). After 90 days, the CSNT rats displayed higher TH activity than the sham-operated animals in caudal A(1)C(1) (+51 %), caudal A(2)C(2) (+129 %), A(5) (+216 %) and A(6)cells (+79 %).4. It is concluded that HVR following CSNT is associated with a profound functional reorganisation of the central O-2 chemoreflex pathway including changes in ventilatory pattern and medullary catecholaminergic activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 12:46:46