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Titolo:
Regulation of extracellular concentrations of 5-hydroxytryptamine (5-HT) in mouse striatum by 5-HT1A and 5-HT1B receptors
Autore:
Knobelman, DA; Kung, HF; Lucki, I;
Indirizzi:
Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Psychiat, Philadelphia, PA 19104 USA Univ Penn, Dept Pharmacol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Pharmacol, Philadelphia, PA 19104 USA Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA Univ Penn PhiladelphiaPA USA 19104 pt Radiol, Philadelphia, PA 19104 USA
Titolo Testata:
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
fascicolo: 3, volume: 292, anno: 2000,
pagine: 1111 - 1117
SICI:
0022-3565(200003)292:3<1111:ROECO5>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN UPTAKE INHIBITOR; RAT-BRAIN; INVIVO MICRODIALYSIS; IN-VIVO; RELEASE; AGONIST; DORSAL; HIPPOCAMPUS; AUTORECEPTORS; ANTAGONISTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Lucki, I Univ Penn, Dept Psychiat, 3600 Market St,Room 748, Philadelphia, PA 19104 USA Univ Penn 3600 Market St,Room 748 Philadelphia PA USA 19104 4 USA
Citazione:
D.A. Knobelman et al., "Regulation of extracellular concentrations of 5-hydroxytryptamine (5-HT) in mouse striatum by 5-HT1A and 5-HT1B receptors", J PHARM EXP, 292(3), 2000, pp. 1111-1117

Abstract

The ability of selective serotonin (5-HT) receptor agonists to reduce the extracellular concentration of 5-HT was examined in the striatum of awake, unrestrained mice by in vivo microdialysis. Systemic administration of either 8-OH-PIPAT {R-(+)-trans-8-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'-propenyl)]aminotetralin}, a novel 5-HT1A receptor agonist, or CP 94,253, a selective5-HT1B receptor agonist, resulted in significant dose-related reductions of striatal 5-HT. The effect of 8-OH-PIPAT (1.0 mg/kg) was blocked by pretreatment with WAY 100635 (0.1 mg/kg), a selective 5-HT1A receptor antagonist,but it was not blocked by pretreatment with GR 127935 (0.056 mg/kg), a selective 5-HT1B/1D receptor antagonist. The effect of CP 94,253 (1.0 mg/kg) was blocked by pretreatment with GR 127935 (0.056 mg/kg) but was not blockedby pretreatment with WAY 100635 (0.1 mg/kg). Neither WAY 100635 nor GR 127935 altered extracellular 5-HT levels at the doses that were able to completely block the effects of either 8-OH-PIPAT or CP 94,253. The present findings suggest that, on systemic administration, both 8-OH-PIPAT and CP 94,253are potent and selective agonists at the somatodendritic 5-HT1A autoreceptor and terminal 5-HT1B/1D autoreceptor, respectively, and are each able to cause decreases in extracellular levels of 5-HT in the mouse striatum by activating a distinct set of receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 21:25:51