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Titolo:
Pivotal role of CCR1-positive leukocytes in bleomycin-induced lung fibrosis in mice
Autore:
Tokuda, A; Itakura, M; Onai, N; Kimura, H; Kuriyama, T; Matsushima, K;
Indirizzi:
Univ Tokyo, Sch Med, Dept Mol Prevent Med, Bunkyo Ku, Tokyo 1130033, JapanUniv Tokyo Tokyo Japan 1130033 vent Med, Bunkyo Ku, Tokyo 1130033, Japan Chiba Univ, Sch Med, Dept Chest Med, Chiba 280, Japan Chiba Univ Chiba Japan 280 iv, Sch Med, Dept Chest Med, Chiba 280, Japan
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 5, volume: 164, anno: 2000,
pagine: 2745 - 2751
SICI:
0022-1767(20000301)164:5<2745:PROCLI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED PULMONARY FIBROSIS; C CHEMOKINE RECEPTOR; BRONCHOALVEOLAR LAVAGE; HOST-DEFENSE; EXPRESSION; DISEASE; CCR1; RECRUITMENT; LACKING; INJURY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Matsushima, K Univ Tokyo, Sch Med, Dept Mol Prevent Med, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan Univ Tokyo 7-3-1 Hongo Tokyo Japan 1130033 o 1130033, Japan
Citazione:
A. Tokuda et al., "Pivotal role of CCR1-positive leukocytes in bleomycin-induced lung fibrosis in mice", J IMMUNOL, 164(5), 2000, pp. 2745-2751

Abstract

We have investigated the involvement of chemokine receptor CCR1-positive cells in bleomycin-induced lung injury, a model of pulmonary fibrosis. Afterbleomycin challenge in C57BL/6J mice, the expression of CCR1 mRNA increased and peaked at day 7, which paralleled to the expression of its ligands, macrophage-inflammatory protein-1 alpha and RANTES, Immunohistochemical study showed that CCR1-positive cells accumulated in the interstitial inflammatory site. Furthermore, the treatment of anti-CCR1 Ab significantly reduced the accumulation of inflammatory cells and collagen deposition, resulting in dramatic improvement of survival. These results suggest that CCR1-positive cells play significant roles in the pathogenesis of pulmonary fibrosis subsequent to bleomycin-induced lung injury, and that CCR1 could be a novel molecular target for intervention therapy against pulmonary fibrosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 16:40:43