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Titolo:
Lck domains differentially contribute to pre-T cell receptor (TCR)- and TCR-alpha/beta-regulated developmental transitions
Autore:
Lin, K; Longo, NS; Wang, X; Hewitt, JA; Abraham, KM;
Indirizzi:
Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 l & Immunol, Baltimore, MD 21201 USA Univ Maryland, Sch Med, Grad Program Mol & Cellular Biol, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 llular Biol, Baltimore, MD 21201 USA
Titolo Testata:
JOURNAL OF EXPERIMENTAL MEDICINE
fascicolo: 4, volume: 191, anno: 2000,
pagine: 703 - 715
SICI:
0022-1007(20000221)191:4<703:LDDCTP>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-TYROSINE KINASE; AMINO-TERMINAL DOMAIN; THYMOCYTE DEVELOPMENT; MICE LACKING; LYMPHOCYTE DEVELOPMENT; SIGNAL TRANSDUCTION; LINEAGE COMMITMENT; ALLELIC EXCLUSION; PROFOUND BLOCK; ACTIVATED LCK;
Keywords:
thymus; signal transduction; cellular differentiation; protein kinases; lymphocytes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Abraham, KM Univ Maryland, Sch Med, Dept Microbiol & Immunol, BRB 13-045,655 W Baltimore St, Baltimore, MD 21201 USA Univ Maryland BRB 13-045,655 W Baltimore St Baltimore MD USA 21201
Citazione:
K. Lin et al., "Lck domains differentially contribute to pre-T cell receptor (TCR)- and TCR-alpha/beta-regulated developmental transitions", J EXP MED, 191(4), 2000, pp. 703-715

Abstract

Maturational changes at the CD4(-)CD8(-) double negative (DN) to CD4(+)CD8(+) double positive (DP) transition are dependent: on signals generated viathe pre-T cell receptor (TCR) and the nonreceptor protein tyrosine kinase p56(lck) (Lck). How Lck activities are stimulated or relayed after pre-TCR formation remains obscure. Our structure-function mapping of Lck thymopoietic properties reveals that the noncatalytic domains of Lck are specialized to signal efficient cellular expansion at DN to DP transition. Moreover, although substitution of the Lck catalytic domain with FynT sequences minimally impacts DP development, single positive thymocytes are most efficiently produced in the presence of kinases containing both the NH2-terminal and catalytic regions of Lck, These findings demonstrate that the Lck structure is uniquely adapted to mediate signals at both major transitions in thymopoiesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:46:41