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Titolo:
Effects of an endothelin receptor antagonist TAK-044 on myocardial energy metabolism in ischemia/reperfused rat hearts
Autore:
Iimuro, M; Kaneko, M; Matsumoto, Y; Fujise, Y; Watanabe, T; Hayashi, H;
Indirizzi:
Hamamatsu Univ, Sch Med, Dept Internal Med 3, Hamamatsu, Shizuoka 4313124,Japan Hamamatsu Univ Hamamatsu Shizuoka Japan 4313124 u, Shizuoka 4313124,Japan Hamamatsu Univ, Sch Med, Div Chem, Hamamatsu, Shizuoka 4313124, Japan Hamamatsu Univ Hamamatsu Shizuoka Japan 4313124 , Shizuoka 4313124, Japan Hamamatsu Univ, Sch Med, Photon Med Res Ctr, Hamamatsu, Shizuoka 4313124, Japan Hamamatsu Univ Hamamatsu Shizuoka Japan 4313124 , Shizuoka 4313124, Japan Takeda Chem Ind Ltd, Osaka 532, Japan Takeda Chem Ind Ltd Osaka Japan 532 akeda Chem Ind Ltd, Osaka 532, Japan
Titolo Testata:
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
fascicolo: 3, volume: 35, anno: 2000,
pagine: 403 - 409
SICI:
0160-2446(200003)35:3<403:EOAERA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFARCT SIZE; ISCHEMIA-REPERFUSION; VENTRICULAR MYOCYTES; INJURY; MECHANISMS; INHIBITION; CELLS; MODEL;
Keywords:
endothelin; NMR; high-energy phosphate metabolism; hydrogen peroxide; TAK-044; reperfusion injury;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Iimuro, M Hamamatsu Univ, Sch Med, Dept Internal Med 3, 3600 Handa Cho, Hamamatsu, Shizuoka 4313124, Japan Hamamatsu Univ 3600 Handa Cho Hamamatsu Shizuoka Japan 4313124 n
Citazione:
M. Iimuro et al., "Effects of an endothelin receptor antagonist TAK-044 on myocardial energy metabolism in ischemia/reperfused rat hearts", J CARDIO PH, 35(3), 2000, pp. 403-409

Abstract

The purpose of this study was to investigate the effects of an endothelin-receptor antagonist TAK-O44 on functional defects and metabolic derangementin myocardial ischemia/reperfusion injury. We sequentially measured high-energy phosphate metabolites and intracellular pH by phosphorus magnetic resonance spectroscopy during 35-min global ischemia followed by 60-min reperfusion in Langendorff-perfused rat hearts. TAK-044 (initial loading by 3 mg/kg followed by perfusion with 100 nM solution) was administered in two different ways: before ischemia or immediately after reperfusion. in addition, we investigated the effects of TAK-044 on functional defects and metabolic alterations induced by hydrogen peroxide (200 mu M, 30 min). The recoveriesof left ventricular developed pressure after reperfusion in TAK-044 groups(51 +/- 12% in TAK-I, 61 +/- 12% in TAK-R) were better than in control (10+/- 5% in control; p < 0.01). Increases in left ventricular end-diastolic pressure (LVEDP) in TAK-044 groups (22 +/- 5 mm Hg in TAK-I, 24 +/- 5 mm Hgin TAK-R) were less than in control (38 +/- 3 mm Hg; p < 0.01). Adenosine triphosphate (ATP) (33 +/- 5% in TAK-I, 28 +/- 4% in TAK-R) in TAK-044 groups were higher than in control (13 +/- 3%; p < 0.01). The creatine phosphokinase (CPK) release during reperfusion in TAK-044 groups (3.3 +/- 1.5 IU/g wet wt/60 min in TAK-I, 3.5 +/- 2.5 IU/g wet wt/60 min in TAK-R) were lowerthan in control (13.8 +/- 3.9 IU/g wet wt/60 min; p < 0.05). In contrast, TAK-044 did not attenuate the myocardial injury induced by hydrogen peroxide, TAK-044, even if administered simultaneous with coronary reperfusion, attenuated myocardial ischemia/ reperfusion injury. The energy-preservative effect of TAK-044 could be associated with the good functional recovery in ische- mia/reperfused rat hearts.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 18:21:06