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Titolo:
Group A streptococci in the 1990s
Autore:
Efstratiou, A;
Indirizzi:
WHO Collaborating Ctr Diphtheria & Streptococcal, PHLS Resp & Syst Infect Lab, Cent Publ Hlth Lab, London NW9 5HT, England WHO Collaborating Ctr Diphtheria & Streptococcal London England NW9 5HT
Titolo Testata:
Journal of antimicrobial chemotherapy
, volume: 45, anno: 2000, supplemento:, T1
pagine: 3 - 12
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROUP-A STREPTOCOCCI; HORIZONTAL GENE-TRANSFER; SHOCK-LIKE SYNDROME; INVASIVE GROUP; CHANGING EPIDEMIOLOGY; CLINICAL-FEATURES; M-PROTEIN; RHEUMATIC-FEVER; INFECTIONS; PYOGENES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Efstratiou, A WHO Collaborating Ctr Diphtheria & Streptococcal, PHLS Resp & Syst Infect Lab, Cent Publ Hlth Lab, 61 Colindale Ave, London NW9 5HT, England WHO Collaborating Ctr Diphtheria & Streptococcal 61 Colindale Ave London England NW9 5HT
Citazione:
A. Efstratiou, "Group A streptococci in the 1990s", J ANTIMICRO, 45, 2000, pp. 3-12

Abstract

The last decade has witnessed a remarkable change in the epidemiology of group A streptococcal infections. There has been a marked increase globally in the reporting of invasive infections caused by Streptococcus pyogenes, Lancefield group A streptococci. Many of these cases were deep-seated infections associated with shock and multi-organ failure and are defined as streptococcal toxic shock syndrome. In addition, reports of streptococcal sequelae, in particular, acute rheumatic fever, have re-emerged and remain a serious health threat in developed countries. It appears that these infections are related to the type distributions of the organism among the general population, with the re-emergence of more 'virulent' strains, such as the M1 serotype which in earlier decades was primarily seen in cases of either superficial disease or scarlet fever. Population-based surveillance studies have clearly indicated the importance and relevance of type identification forepidemiological purposes. There have also been suggestions that certain extracellular: products and toxins play a major role in the so-called 'increased virulence' of the organism; these include cell surface molecules such as the M protein, opacity factor, the hyaluronic acid capsule, C5a peptidaseand streptococcal inhibitor of complement (SIC), in addition to secreted proteins, pyrogenic exotoxins, cysteine proteinase, streptolysins O and S, hyaluronidase, streptokinase and other enzymes. All these factors, and events during the last decade, strongly emphasize the need for a better understanding of the epidemiology, pathogenesis, treatment and prevention of group A streptococcal infections.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 11:08:59