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Titolo:
Mutations in zinc-binding domains of p53 as a prognostic marker of esophageal-cancer patients
Autore:
Kihara, C; Seki, T; Furukawa, Y; Yamana, H; Kimura, Y; van Schaardenburgh, P; Hirata, K; Nakamura, Y;
Indirizzi:
Univ Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab,Minato Ku, Tokyo 1088639, Japan Univ Tokyo Tokyo Japan 1088639 l Med Lab,Minato Ku, Tokyo 1088639, Japan Kurume Univ, Sch Med, Dept Surg, Kurume, Fukuoka 8300011, Japan Kurume Univ Kurume Fukuoka Japan 8300011 , Kurume, Fukuoka 8300011, Japan Sapporo Med Univ, Dept Surg 1, Sch Med, Chuo Ku, Sapporo, Hokkaido 0600061, Japan Sapporo Med Univ Sapporo Hokkaido Japan 0600061 , Hokkaido 0600061, Japan
Titolo Testata:
JAPANESE JOURNAL OF CANCER RESEARCH
fascicolo: 2, volume: 91, anno: 2000,
pagine: 190 - 198
SICI:
0910-5050(200002)91:2<190:MIZDOP>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
BREAST-CANCER; GENE-MUTATIONS; COLORECTAL-CANCER; SEQUENCE-ANALYSIS; SURVIVAL; CARCINOMA; CHEMOTHERAPY; MUTANTS; TP53; TERM;
Keywords:
p53; mutation; zinc-binding domains; esophageal cancer; prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Nakamura, Y Univ Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab,MinatoKu, 4-6-1 Shirokanedai, Tokyo 1088639, Japan Univ Tokyo 4-6-1 ShirokanedaiTokyo Japan 1088639 8639, Japan
Citazione:
C. Kihara et al., "Mutations in zinc-binding domains of p53 as a prognostic marker of esophageal-cancer patients", JPN J CANC, 91(2), 2000, pp. 190-198

Abstract

Some investigators have suggested that mutations of the p53 gene may be molecular markers for poor prognosis of cancer patients, although others havereported conflicting results. We examined esophageal cancers from 138 patients to investigate whether mutational status of p53 could be correlated either with prognosis or with response to chemotherapy or radiation. We detected p53 mutations in the tumors of 78 (56.5%) patients, Kaplan-Meier analysis showed that these 78 patients tended to have shorter survival times and greater resistance to either form of therapy than patients whose tumors carried two wild-type p53 alleles, The difference became more evident when we focused on mutations in zinc-binding domains of p53 (L2 and L3); the prognosis was significantly poorer among the 29 patients with tumors in this category than among patients whose tumors had no p53 mutations, or p53 mutations outside L2 or L3 (P = 0,0060). Moreover, those tumors as a group were more resistant to chemotherapy or radiation than the others (P = 0,0105), Our results underscore the importance of the zinc-binding domains of p53 with respect to clinical prognosis for patients with esophageal carcinomas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 13:01:59