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Titolo:
Tissue specific expression of Yrk kinase: implications for differentiationand inflammation
Autore:
Martins-Green, M; Bixby, JL; Yamamoto, T; Graf, T; Sudol, M;
Indirizzi:
Univ Calif Riverside, Dept Cell Biol & Neurosci, Riverside, CA 92521 USA Univ Calif Riverside Riverside CA USA 92521 osci, Riverside, CA 92521 USA Univ Miami, Dept Mol & Cellular Pharmacol, Miami, FL 33101 USA Univ MiamiMiami FL USA 33101 l & Cellular Pharmacol, Miami, FL 33101 USA Univ Miami, Neurosci Program, Miami, FL 33101 USA Univ Miami Miami FL USA33101 iami, Neurosci Program, Miami, FL 33101 USA Univ Tokyo, Inst Med Sci, Dept Signal Transduct, Tokyo 108, Japan Univ Tokyo Tokyo Japan 108 Sci, Dept Signal Transduct, Tokyo 108, Japan European Mol Biol Lab, D-69117 Heidelberg, Germany European Mol Biol Lab Heidelberg Germany D-69117 117 Heidelberg, Germany Mt Sinai Med Ctr, Dept Biochem, New York, NY 10029 USA Mt Sinai Med Ctr New York NY USA 10029 pt Biochem, New York, NY 10029 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
fascicolo: 3, volume: 32, anno: 2000,
pagine: 351 - 364
SICI:
1357-2725(200003)32:3<351:TSEOYK>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-TYROSINE KINASES; CHICKEN ERYTHROID-CELLS; CENTRAL-NERVOUS-SYSTEM; ROUS-SARCOMA VIRUS; PROTOONCOGENE PRODUCT; NEURAL TISSUES; CELLULAR-YES; RAT-BRAIN; C-SRC; RECEPTOR;
Keywords:
neuronal; hematopoietic; epithelial; injury; wound-healing;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Martins-Green, M Univ Calif Riverside, Dept Cell Biol & Neurosci, Riverside, CA 92521 USA Univ Calif Riverside Riverside CA USA 92521 CA 92521 USA
Citazione:
M. Martins-Green et al., "Tissue specific expression of Yrk kinase: implications for differentiationand inflammation", INT J BIO C, 32(3), 2000, pp. 351-364

Abstract

The Src family of proto-oncogenes is a highly conserved group of non-receptor tyrosine kinases with very similar, but not identical, tissue distributions and functions. Yrk is a recently discovered new member of this family. Here we report the patterns of expression of this kinase in a variety of chicken tissues during development and after hatching, and experiments that correlate some of the observed patterns of expression with potential functions. The results show that the Yrk protein is primarily found in neuronal and epithelial cells and in monocyte/macrophages. In neuronal tissues of hatched chicks. Yrk is expressed in Purkinje cells, in the gigantocellularis of the brain-stem, and in retinal ganglion cells. In addition, staining for this kinase is also seen as thread-like and punctate patterns suggesting staining in neurites and growth cones. Epithelial cells express Yrk in the stomach during late developmental stages and after hatching but, in other epithelia such as in the peridermis, intestine and kidney, expression is high during development but low (skin) or undetectable (intestine and kidney) after hatching. These results suggest that Yrk may have several functional roles, specifically in cell migration and/or differentiation during neuronal and epithelial cell development and in maintenance of the differentiated phenotype. In this study we also show that significant levels of Yrk are detected in monocytes of the blood and in tissue macrophages. Analysis of chicken hematopoietic cell lines confirmed the expression of Yrk in cells of monocyte/macrophage lineage and show for the first time in experimentally-induced inflammation that Yrk kinase activity is high during the period of monocyte infiltration, raising the possibility that this kinase plays a role ininflammation and/or response to injury. (C) 2000 Elsevier Science Ltd. Allrights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 06:22:22