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Titolo:
Anti-oxidants as modulators of immune function
Autore:
De la Fuente, M; Victor, VM;
Indirizzi:
Univ Complutense, Fac Biol, Dept Anim Physiol, E-28040 Madrid, Spain Univ Complutense Madrid Spain E-28040 nim Physiol, E-28040 Madrid, Spain
Titolo Testata:
IMMUNOLOGY AND CELL BIOLOGY
fascicolo: 1, volume: 78, anno: 2000,
pagine: 49 - 54
SICI:
0818-9641(200002)78:1<49:AAMOIF>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
N-ACETYLCYSTEINE; MACROPHAGE FUNCTION; VITAMIN-E; IN-VITRO; ANTIOXIDANTS; CELLS;
Keywords:
ageing; anti-oxidant; endotoxic shock; immune function; lymphocyte;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: De la Fuente, M Univ Complutense, Fac Ciencias Biol, Dept Biol Anim FisiolAnim 2, Av Complutense S-N, E-28040 Madrid, Spain Univ Complutense Av Complutense S-N Madrid Spain E-28040
Citazione:
M. De la Fuente e V.M. Victor, "Anti-oxidants as modulators of immune function", IMM CELL B, 78(1), 2000, pp. 49-54

Abstract

In order to confirm the hypothesis of the immunomodulating action of anti-oxidants (bringing back altered immune function to more optimum values), the possibility that anti-oxidants may be useful in two experimental models of altered immune function has been studied. The first is a pathological model, that is, lethal murine endotoxic shock caused by an LPS injection of 100 mg/kg, in which the lymphocytes show increased adherence and depressed chemotaxis. The injection of N-acetylcysteine (150 mg/kg), which increased both functions in control animals, decreased adherence and increased chemotaxis in mice with endotoxic shock. The second is a physiological model; aged human subjects (70 +/- 5-year-old men) who, in their largest segment of population ('standard' group) showed an increased lymphocyte adherence and decreased lymphoproliferative response to mitogens compared with younger adults. The ingestion of vitamin E (200 mg daily for 3 months in this standard group) lowered adherence and stimulated lymphoproliferation. However, a smaller segment of the human population tested showed 'non-standard' values in these lymphocyte functions, that is, very low adherence and very high proliferation. In those subjects, vitamin E showed the opposite effects, namely adherence increase and depressed lymphoproliferation. Tn both age groups ofmen, these functions reached adult levels after vitamin E ingestion. Thesedata suggest that anti-oxidants preserve adequate function of immune cellsagainst homeostatic disturbances such as those caused by endotoxic shock and ageing.

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Documento generato il 15/07/20 alle ore 03:09:01