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Titolo:
Murine bone marrow-derived mast cells exhibit evidence of both apoptosis and oncosis after IL-3 deprivation
Autore:
Park, BS; Kim, GC; Baek, SJ; Kim, ND; Kim, YS; Kim, SK; Jeong, MH; Lim, YJ; Yoo, YH;
Indirizzi:
Dong A Univ, Coll Med, Dept Anat & Cell Biol, Inst Med Sci, Pusan 602103, South Korea Dong A Univ Pusan South Korea 602103 Med Sci, Pusan 602103, South Korea Pusan Natl Univ, Coll Dent, Dept Oral Anat & Cell Biol, Pusan 609735, South Korea Pusan Natl Univ Pusan South Korea 609735 Biol, Pusan 609735, South Korea Pusan Natl Univ, Coll Pharm, Dept Pharm, Pusan 609735, South Korea Pusan Natl Univ Pusan South Korea 609735 harm, Pusan 609735, South Korea Dong A Univ, Coll Med, Dept Plast Surg, Pusan 602103, South Korea Dong A Univ Pusan South Korea 602103 ast Surg, Pusan 602103, South Korea Dong A Univ, Coll Med, Dept Microbiol, Pusan 602103, South Korea Dong A Univ Pusan South Korea 602103 icrobiol, Pusan 602103, South Korea Dong A Univ, Coll Med, Dept Parasitol, Pusan 602103, South Korea Dong A Univ Pusan South Korea 602103 arasitol, Pusan 602103, South Korea
Titolo Testata:
IMMUNOLOGICAL INVESTIGATIONS
fascicolo: 1, volume: 29, anno: 2000,
pagine: 51 - 60
SICI:
0882-0139(2000)29:1<51:MBMMCE>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEATH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Yoo, YH Dong A Univ, Coll Med, Dept Anat & Cell Biol, Inst Med Sci, Pusan 602103, South Korea Dong A Univ Pusan South Korea 602103 , Pusan 602103, South Korea
Citazione:
B.S. Park et al., "Murine bone marrow-derived mast cells exhibit evidence of both apoptosis and oncosis after IL-3 deprivation", IMMUNOL INV, 29(1), 2000, pp. 51-60

Abstract

IL-3 deprivation has been reported to induce apoptosis of bone marrow-derived mast cells. In order to evaluate this type of cell death further, we employed trypan blue and propidium iodide stainings, photometric enzyme immunoassay, fluorescence measurement of caspase-3, DNA electrophoresis, flow cytometry and transmission electron microscopy. In this experiment, although several evidences supporting apoptosis were demonstrated some findings werenot consistent with typical apoptosis. On the other hand, electron microscopical observation demonstrated that most cells from all the time phases after IL-3 deprivation showed the morphology of typical oncosis, i.e. cell swelling, disintegration of ultrastructure and subsequent karyolysis. Only a small number of cells from the later time phases showed apoptotic morphology. We here suggest that BMMCs undergo both apoptosis and oncosis after IL-3deprivation and that the dominant type of prelethal change is oncosis in all time phases, although apoptosis also plays a partial role in the late time phases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 12:47:25