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Titolo:
Influence of hypertension, left ventricular hypertrophy, and left ventricular systolic dysfunction on plasma N terminal proBNP
Autore:
Talwar, S; Siebenhofer, A; Williams, B; Ng, L;
Indirizzi:
Leicester Royal Infirm, Dept Med & Therapeut, Leicester LE2 7LX, Leics, England Leicester Royal Infirm Leicester Leics England LE2 7LX LX, Leics, England Univ Leicester, Inst Cardiovasc Res, Leicester, Leics, England Univ Leicester Leicester Leics England sc Res, Leicester, Leics, England
Titolo Testata:
HEART
fascicolo: 3, volume: 83, anno: 2000,
pagine: 278 - 282
SICI:
1355-6037(200003)83:3<278:IOHLVH>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN NATRIURETIC PEPTIDE; ACUTE MYOCARDIAL-INFARCTION; ECHOCARDIOGRAPHIC DETERMINATION; EJECTION FRACTION; CARDIAC HORMONE; HEART-FAILURE; MASS; RISK; BNP;
Keywords:
hypertension; brain natriuretic peptide; left ventricular hypertrophy; left ventricular systolic dysfunction; chemiluminescence;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Ng, L Leicester Royal Infirm, Dept Med & Therapeut, Robert Kilpatrick ClinSci Bldg, Leicester LE2 7LX, Leics, England Leicester Royal Infirm Robert Kilpatrick Clin Sci Bldg Leicester Leics England LE2 7LX
Citazione:
S. Talwar et al., "Influence of hypertension, left ventricular hypertrophy, and left ventricular systolic dysfunction on plasma N terminal proBNP", HEART, 83(3), 2000, pp. 278-282

Abstract

Objectives-To examine the relation between plasma concentration of the N terminal of the precursor of brain natriuretic peptide (NT proBNP), left ventricular hypertrophy (LVH), and left ventricular systolic dysfunction (LVSD) in patients with a history of hypertension. Design-Prospective study. Setting-Teaching hospital based study. Patients-NT proBNP concentrations were determined in five groups of individuals. Group 1: 15 echocardiographic normal controls; group 2: 22 patients with hypertension, normal left ventricular systolic function, and no LVH; group 3: 24 patients with hypertension, normal left ventricular systolic function, and LVH; group 4: 13 patients with history of hypertension, no history of ischaemic heart disease, and left ventricular wall motion index WMI) between 1.9-1.3; and group 5:17 patients with a history of hypertension, nohistory of ischaemic heart disease, and WMI < 1.2. Results-Median (range) NT proBNP concentrations tin fmol/ml) for groups 1-5, respectively, were: 129.4 (53.6-159.7), 147.4 (54.3-730.5), 137.1 (35.8-403.9), 356.7 (124.4-934.4), and 493.5 (248.9-909). Mean log NT proBNP differed among all five groups (p < 0.0001), and between groups 1 and 5 versus groups 1-3 (p < 0.0001), and group 1 versus group 5 (p = 0.02) only. Conclusions-The results suggest that the presence of hypertension with or without LVH land normal left ventricular systolic function) does not affectNT proBNP concentrations. Moreover, there is a significant rise in NT proBNP only when LVSD develops in hypertension. Thus, NT proBNP remains a useful diagnostic aid for LVSD, even in hypertensive patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 00:42:20