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Titolo:
Biological repair of thyroid cartilage defects by osteogenic protein-1 (bone morphogenetic protein-7) in dog
Autore:
Katic, V; Majstorovic, L; Maticic, D; Pirkic, B; Yin, S; Kos, J; Martinovic, S; McCartney, JE; Vukicevic, S;
Indirizzi:
Univ Zagreb, Dept Anat, Sch Med, Zagreb 10000, Croatia Univ Zagreb Zagreb Croatia 10000 pt Anat, Sch Med, Zagreb 10000, Croatia Clin Hosp Ctr Zagreb, Dept Otorhinolaryngol, Zagreb, Croatia Clin Hosp CtrZagreb Zagreb Croatia t Otorhinolaryngol, Zagreb, Croatia Sch Vet, Dept Surg Orthoped & Ophthalmol, Zagreb, Croatia Sch Vet ZagrebCroatia Dept Surg Orthoped & Ophthalmol, Zagreb, Croatia Stryker Biotech, Hopkinton, MA 01748 USA Stryker Biotech Hopkinton MA USA01748 r Biotech, Hopkinton, MA 01748 USA Creat BioMol, Hopkinton, MA 01748 USA Creat BioMol Hopkinton MA USA 01748Creat BioMol, Hopkinton, MA 01748 USA
Titolo Testata:
GROWTH FACTORS
fascicolo: 3, volume: 17, anno: 2000,
pagine: 221 -
SICI:
0897-7194(2000)17:3<221:BROTCD>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL LARYNGOTRACHEAL RECONSTRUCTION; VERTICAL PARTIAL LARYNGECTOMY; HUMAN EMBRYONIC-DEVELOPMENT; BABOON PAPIO-URSINUS; ARTICULAR CHONDROCYTES; BETA-SUPERFAMILY; CANINE MODEL; LONG BONES; DIFFERENTIATION; EXPRESSION;
Keywords:
osteogenic protein-1; bone morphogenetic protein-7; cartilage repair; dog larynx;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Vukicevic, S Univ Zagreb, Dept Anat, Sch Med, Salata 11,Box 916, Zagreb 10000, Croatia Univ Zagreb Salata 11,Box 916 Zagreb Croatia 10000 , Croatia
Citazione:
V. Katic et al., "Biological repair of thyroid cartilage defects by osteogenic protein-1 (bone morphogenetic protein-7) in dog", GROW FACTOR, 17(3), 2000, pp. 221

Abstract

The efficacy of human recombinant osteogenic protein-1 (OP-1; bone morphogenetic protein-7) in regeneration of dog larynx,vas examined by treating thyroid cartilage defects (1.5 cm(2)) in dogs with thyroid allografts coveredwith host perichondrium or fascia, Prior to implantation allografts were frozen, thawed and demineralized, The treatment groups were as follows: I - Allograft control implant (n = 3); n - Implants coated with 500 mu g OP-1 (n = 4); III - Implants coated with 100 mu g OP-1 (n = 3); IV - Implants coated with 500 mu g OP-l and covered with neck fascia (n = 3); and V - Implants extracted with 1 M NaCl and guanidine hydrochloride, and coated,vith 500mu g OP-1 (n = 4). Dogs were sacrificed four months following surgery. Each larynx was removed, carefully dissected and a three-dimensional reconstruction of the defect area was performed on serial sections. The results revealed that the implants of control dogs remained intact with no apparent reduction in size and new tissue formation. OP-1 enriched thyroid allografts, dose dependently induced bone, cartilage and Ligament-like structures comprising up to 80% of the total regenerated defect area. Boundaries of the defects healed by formation of new bone when bone resided within the old thyroid cartilage layers. Old cartilage not containing bone within its layers healed by complete integration with newly formed cartilage. Both new bone andcartilage were embedded into layers of new ligament-like tissue which expressed specific morphologic and molecular markers. The three newly formed tissues were tightly connected into a "bone-cartilage-ligament continuum" of tissues, suggesting that OP-1 served as a multiple tissue morphogen, in this specific microenvironment.

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Documento generato il 07/04/20 alle ore 02:46:49