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Titolo:
TAP OFF - TUMORS ON
Autore:
SELIGER B; MAEURER MJ; FERRONE S;
Indirizzi:
UNIV MAINZ,DEPT INTERNAL MED,DIV HEMATOL ONCOL D-55131 MAINZ GERMANY UNIV MAINZ,DEPT MED MICROBIOL D-55131 MAINZ GERMANY NEW YORK MED COLL,DEPT MICROBIOL & IMMUNOL VALHALLA NY 10595
Titolo Testata:
Immunology today
fascicolo: 6, volume: 18, anno: 1997,
pagine: 292 - 299
SICI:
0167-5699(1997)18:6<292:TO-TO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOLYTIC T-LYMPHOCYTES; CLASS-I MOLECULES; THYMUS-LEUKEMIA ANTIGEN; SQUAMOUS-CELL CARCINOMA; HUMAN-MELANOMA; INFILTRATING LYMPHOCYTES; PEPTIDE TRANSPORTER; HLA-A2 MELANOMAS; ENCODED TRANSPORTER; DOWN-REGULATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
95
Recensione:
Indirizzi per estratti:
Citazione:
B. Seliger et al., "TAP OFF - TUMORS ON", Immunology today, 18(6), 1997, pp. 292-299

Abstract

The molecular characterization of T-cell-defined tumor-associated antigens has provided targets for cell-mediated immunotherapy for malignant diseases. The success of this strategy is negatively influenced by structural and functional abnormalities of major histocompatibility complex (MHC) class I molecules, which provide tumor cells with resistance to T-cell-mediated immune recognition. This article reviews the physiology of the MHC class I processing machinery and describes the deficiencies of this pathway in malignant cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 05:37:57