Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Correlation between the immune response elicited in rabbits by env-recombinant avipox vaccines and the inhibition of HIV-1-specific functions
Autore:
Radaelli, A; Gimelli, M; Zanotto, C; Morghen, CD;
Indirizzi:
Univ Milan, Dept Pharmacol, I-20129 Milan, Italy Univ Milan Milan Italy I-20129 lan, Dept Pharmacol, I-20129 Milan, Italy Univ Milan, Inst Pharmacol Sci, I-20133 Milan, Italy Univ Milan Milan Italy I-20133 Inst Pharmacol Sci, I-20133 Milan, Italy Univ Milan, CNR, Cellular & Mol Pharmacol Ctr, I-20129 Milan, Italy Univ Milan Milan Italy I-20129 & Mol Pharmacol Ctr, I-20129 Milan, Italy
Titolo Testata:
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
fascicolo: 3, volume: 27, anno: 2000,
pagine: 211 - 218
SICI:
0928-8244(200003)27:3<211:CBTIRE>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; MACACA-NEMESTRINA; NEUTRALIZING ANTIBODIES; GENETIC-VARIATION; PROTECTION; INFECTION; TYPE-1; HIV-1; CHIMPANZEES; AIDS;
Keywords:
live recombinant vaccine; avipox virus; epitope mapping; animal model;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Morghen, CD Univ Milan, Dept Pharmacol, Via Vanvitelli 32, I-20129 Milan, Italy Univ Milan Via Vanvitelli 32 Milan Italy I-20129 Milan, Italy
Citazione:
A. Radaelli et al., "Correlation between the immune response elicited in rabbits by env-recombinant avipox vaccines and the inhibition of HIV-1-specific functions", FEMS IM MED, 27(3), 2000, pp. 211-218

Abstract

The fine immunoreactivity of the rabbit humoral response elicited by four env-recombinant avipoxviruses and their ability to stimulate a memory T-cell response and a protective immunity have been studied. The antibody specificity was compared with the serum neutralizing activity and virus-specific T-cell proliferative response. Resistance to challenge by cell-associated HIV-1 was monitored by PCR. Canarypox (CP) and fowlpox (FP) constructs, containing the complete env gene (IS+) from the HIV-1(SF2) strain, induced a higher profile of epitope recognition than their counterparts expressing the env gene deleted of the putative immunosuppressive region (IS-). Serum neutralizing activity was in agreement with fusion inhibition and lymphoproliferative response in rabbits immunized with CPIS+, and only partially with FPIS+. Rabbits failed to be infected, but anti- p55 gag-specific antibodies could be demonstrated by Western blot. This study confirms the ability of these non-replicative live recombinant viruses to elicit a complete immune response, capable of inhibiting specific HIV-I functions. (C) 2000 Federationof European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 05:35:38