Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Metabolism of [I-123]epidepride may affect brain dopamine D-2 receptor imaging with single-photon emission tomography
Autore:
Bergstrom, KA; Yu, MX; Kuikka, JT; Akerman, KK; Hiltunen, J; Lehtonen, J; Halldin, C; Tiihonen, J;
Indirizzi:
Kuopio Univ Hosp, Dept Clin Physiol & Nucl Med, FIN-70210 Kuopio, Finland Kuopio Univ Hosp Kuopio Finland FIN-70210 Med, FIN-70210 Kuopio, Finland MAP Med Technol Oy, FIN-41160 Tikkakoski, Finland MAP Med Technol Oy Tikkakoski Finland FIN-41160 1160 Tikkakoski, Finland Univ Kuopio, Dept Psychiat, FIN-70210 Kuopio, Finland Univ Kuopio KuopioFinland FIN-70210 Psychiat, FIN-70210 Kuopio, Finland Karolinska Hosp, Karolinska Inst, Dept Clin Neurosci, Psychiat Sect, S-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-17176 Sect, S-17176 Stockholm, Sweden Univ Kuopio, Niuvanniemi Hosp, Dept Forens Psychiat, FIN-70240 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70240 Psychiat, FIN-70240 Kuopio, Finland
Titolo Testata:
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
fascicolo: 2, volume: 27, anno: 2000,
pagine: 206 - 208
SICI:
0340-6997(200002)27:2<206:MO[MAB>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
I-123 EPIDEPRIDE;
Keywords:
epidepride; metabolites; single-photon emission tomography; high-performance liquid chromatography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Bergstrom, KA Kuopio Univ Hosp, Dept Clin Physiol & Nucl Med, FIN-70210 Kuopio, Finland Kuopio Univ Hosp Kuopio Finland FIN-70210 Kuopio, Finland
Citazione:
K.A. Bergstrom et al., "Metabolism of [I-123]epidepride may affect brain dopamine D-2 receptor imaging with single-photon emission tomography", EUR J NUCL, 27(2), 2000, pp. 206-208

Abstract

Iodine-123 labelled epidepride is a novel radiopharmaceutical for the study of cerebral dopamine D-2 receptors using single-photon emission tomography (SPET). A lipophilic labelled metabolite of [I-123]epidepride which may enter the brain and hamper the quantitation of receptors has been observed in human plasma. In the present study, gradient high-performance Liquid chromatography (HPLC) was used to investigate the plasma concentration of the lipophilic labelled metabolite and its correlation to SPET imaging of striatal dopamine D-2 receptors, A linear regression fit showed a negative correlation between the amount of the lipophilic labelled metabolite and the striatum to cerebellum ratio (n=16, R=-0.58, P<0.02), suggesting that plasma metabolite analysis is essential when imaging dopamine D-2 receptors with SPET using [I-123]epidepride.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 01:26:35