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Titolo:
Quantitative assessment of regional myocardial blood flow using oxygen-15-labelled water and positron emission tomography: a multicentre evaluation in Japan
Autore:
Iida, H; Yokoyama, I; Agostini, D; Banno, T; Kato, T; Ito, K; Kuwabara, Y; Oda, Y; Otake, T; Tamura, Y; Tadamura, E; Yoshida, T; Tamaki, N;
Indirizzi:
Res Inst Brain & Blood Vessels, Akita, Japan Res Inst Brain & Blood Vessels Akita Japan Blood Vessels, Akita, Japan Univ Tokyo, Fac Med, Dept Radiol, Tokyo, Japan Univ Tokyo Tokyo JapanUniv Tokyo, Fac Med, Dept Radiol, Tokyo, Japan Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Tokyo, Japan Univ Tokyo Tokyo Japan Grad Sch Med, Dept Cardiovasc Med, Tokyo, Japan Kyoto Univ, Sch Med, Dept Nucl Med, Kyoto, Japan Kyoto Univ Kyoto JapanKyoto Univ, Sch Med, Dept Nucl Med, Kyoto, Japan Kyushu Univ, Sch Med, Dept Radiol, Fukuoka 812, Japan Kyushu Univ Fukuoka Japan 812 , Sch Med, Dept Radiol, Fukuoka 812, Japan Nagoya Univ, Sch Med, Dept Radiol, Nagoya, Aichi, Japan Nagoya Univ Nagoya Aichi Japan ch Med, Dept Radiol, Nagoya, Aichi, Japan Kyoto Prefectural Univ Med, Dept Internal Med, Kyoto 602, Japan Kyoto Prefectural Univ Med Kyoto Japan 602 nternal Med, Kyoto 602, Japan Nagoya City Univ, Sch Med, Dept Radiol, Nagoya, Aichi, Japan Nagoya City Univ Nagoya Aichi Japan d, Dept Radiol, Nagoya, Aichi, Japan Hokkaido Univ, Sch Med, Dept Nucl Med, Sapporo, Hokkaido 060, Japan Hokkaido Univ Sapporo Hokkaido Japan 060 ed, Sapporo, Hokkaido 060, Japan
Titolo Testata:
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
fascicolo: 2, volume: 27, anno: 2000,
pagine: 192 - 201
SICI:
0340-6997(200002)27:2<192:QAORMB>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; N-13 AMMONIA; FAMILIAL HYPERCHOLESTEROLEMIA; NONINVASIVE QUANTIFICATION; PERFUSION ABNORMALITIES; DIABETES-MELLITUS; LONG-TERM; YOUNG MEN; RESERVE; OXYGEN-15-WATER;
Keywords:
oxygen-15-labelled water; positron emission tomography; regional myocardial blood flow; multicentre study;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Iida, H Natl Cardiovasc Ctr, Res Inst, Dept Invest Radiol, 5-7-1 FujishiroDai, Suita, Osaka 5658565, Japan Natl Cardiovasc Ctr 5-7-1 Fujishiro Dai Suita Osaka Japan 5658565
Citazione:
H. Iida et al., "Quantitative assessment of regional myocardial blood flow using oxygen-15-labelled water and positron emission tomography: a multicentre evaluation in Japan", EUR J NUCL, 27(2), 2000, pp. 192-201

Abstract

Recently, a method has been proposed for the quantitative measurement of regional myocardial blood Flow (MBF) using oxygen-15-labelled water and positron emission tomography (PET), A multicentre project was organized with the intention of evaluating the accuracy of this method, particularly as a multicentre clinical investigative tool. Each of seven institutions performedPET studies on more than five normal volunteers following a specified protocol. The PET study included a tr ans mission scan, a O-15-carbon monoxide static scan and a O-15-water dynamic scant thereby yielding MBF values which should have been independent of the spatial resolution of the PET scanneremployed. Fifty-three subjects (aged 20-63 years, mean+/-SD 36+/-12 years)were studied at rest, and 31 of these subjects were also studied after dipyridamole in five institutions, inter-institution consistency and intra-subject variation in MBF values were then evaluated. MBF averaged for all subjects was 0.93+/-0.34 ml min(-1) g(-1) at rest and 3.40+/-1.73 ml min(-1) g(-1) after the administration of dipyridamole, and the flow reserve (definedas the ratio of the two MBF values) was 3.82+/-2.12 these values are consistent with previous reports, Resting MBF values were significantly correlated with the heart rate-blood pressure product (RPP) (y=0.31+6.56E(-5)x, P<0.010), and RPP was in resting MBF observed in all institutions was well explained by the age-dependent RPP, No significant difference was observed in resting MBF among the institutions. Except in one institution, no significant difference was seen in dipyridamole MBF or mpocnrdial flow reserve, No significnnt difference was found among the myocardial segments. Regional variation was reasonably small in five institutions, but was not acceptable intwo institutions. which was attributed to the scanner performance, These observations suggest that the O-15-water PET technique is useful for a multicentre clinical study if the PET scanner can provide time-activity data with good count statistics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:51:12