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Titolo:
Antidepressant medications and risk for cancer
Autore:
Dalton, SO; Johansen, C; Mellemkjaer, L; Sorensen, HT; McLaughlin, JK; Olsen, J; Olsen, JH;
Indirizzi:
Inst Canc Epidemiol, Danish Canc Soc, DK-2100 Copenhagen, Denmark Inst Canc Epidemiol Copenhagen Denmark DK-2100 -2100 Copenhagen, Denmark Univ Aarhus, Danish Epidemiol Sci Ctr, DK-8000 Aarhus C, Denmark Univ Aarhus Aarhus Denmark C pidemiol Sci Ctr, DK-8000 Aarhus C, Denmark Aarhus Univ Hosp, Dept Med M & V, Clin Epidemiol Res Unit, DK-8000 Aarhus,Denmark Aarhus Univ Hosp Aarhus Denmark DK-8000 Res Unit, DK-8000 Aarhus,Denmark Aalborg Univ Hosp, Aalborg, Denmark Aalborg Univ Hosp Aalborg DenmarkAalborg Univ Hosp, Aalborg, Denmark Int Epidemiol Inst, Rockville, MD USA Int Epidemiol Inst Rockville MD USA nt Epidemiol Inst, Rockville, MD USA
Titolo Testata:
EPIDEMIOLOGY
fascicolo: 2, volume: 11, anno: 2000,
pagine: 171 - 176
SICI:
1044-3983(200003)11:2<171:AMARFC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPITHELIAL OVARIAN-CANCER; DEPRESSION; SMOKING; ENHANCEMENT; POPULATION; GROWTH; DRUGS; MICE;
Keywords:
antidepressant medication; cancer incidence; pharmacoepidemiology; cohort studies; tricyclic antidepressants; monoamine oxidase inhibitors; tetracyclic antidepressants; serotonin reuptake inhibitors; gender;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Johansen, C Inst Canc Epidemiol, Danish Canc Soc, Strandblvd 49, DK-2100 Copenhagen, Denmark Inst Canc Epidemiol Strandblvd 49 Copenhagen Denmark DK-2100
Citazione:
S.O. Dalton et al., "Antidepressant medications and risk for cancer", EPIDEMIOLOG, 11(2), 2000, pp. 171-176

Abstract

Antidepressants appear to promote tumor growth in experimental studies; however, results from epidemiologic studies are inconclusive. We used a population-based cohort study to estimate the incidence of cancer after antidepressant treatment in 39,807 adult users of antidepressants identified in thePrescription Database of the County of North Jutland, Denmark between January 1, 1989 and December 31, 1995. Information on cancer occurrence was obtained from the Danish Cancer Registry. We categorized exposure according touse of tricyclic antidepressants, tetracyclic antidepressants, selective serotonin reuptake inhibitors, or monoamine oxidase inhibitors. In the follow-up period beginning 1 year after first known prescription, there were 966cancers among users of antidepressants; our population estimate suggested an expected number of 946 for an overall standardized incidence ratio of 1.0 (95% confidence interval = 1.0-1.1). Users of tricyclic antidepressants had an excess of non-Hodgkin's lymphoma, with the risk increasing with the number of prescriptions of tricyclic antidepressants. The standardized incidence ratio was 2.5 (95% confidence interval, 1.4-4.2) for those with five or more prescriptions. Our results provide little evidence that antidepressants promote cancer at other sites, except for a possible effect of tricyclic antidepressants and tetracyclic antidepressants on non Hodgkin's lymphoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 10:00:13