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Titolo:
Subpopulations of rat B2(+) neuroblasts exhibit differential neurotrophin responsiveness during sympathetic development
Autore:
Goldhawk, DE; Meakin, SO; Verdi, JM;
Indirizzi:
John P Robarts Res Inst, Neurodegredat Res Grp, London, ON N6A 5K8, CanadaJohn P Robarts Res Inst London ON Canada N6A 5K8 ndon, ON N6A 5K8, Canada Univ Western Ontario, Dept Biochem, London, ON, Canada Univ Western Ontario London ON Canada , Dept Biochem, London, ON, Canada Univ Western Ontario, Dept Physiol, London, ON, Canada Univ Western Ontario London ON Canada , Dept Physiol, London, ON, Canada Univ Western Ontario, Neurosci Program, London, ON, Canada Univ Western Ontario London ON Canada urosci Program, London, ON, Canada
Titolo Testata:
DEVELOPMENTAL BIOLOGY
fascicolo: 2, volume: 218, anno: 2000,
pagine: 367 - 377
SICI:
0012-1606(20000215)218:2<367:SORBNE>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; MICE LACKING GDNF; SENSORY NEURONS; TYROSINE KINASE; MAH CELLS; SIGNAL-TRANSDUCTION; POSTMITOTIC NEURONS; SURVIVAL; EXPRESSION; RECEPTOR;
Keywords:
sympathetic neurogenesis; neuroblast survival; neurotrophins; autocrine survival;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Verdi, JM John P Robarts Res Inst, Neurodegredat Res Grp, 100 Perth Dr, London, ON N6A 5K8, Canada John P Robarts Res Inst 100 Perth Dr London ON Canada N6A 5K8 da
Citazione:
D.E. Goldhawk et al., "Subpopulations of rat B2(+) neuroblasts exhibit differential neurotrophin responsiveness during sympathetic development", DEVELOP BIO, 218(2), 2000, pp. 367-377

Abstract

Sympathetic neurons comprise a population of postmitotic, tyrosine hydroxylase expressing cells whose survival is dependent upon nerve growth factor (NGF) both in vivo and in vitro. However, during development precursors to rat sympathetic neurons in the thoracolumbar region are not responsive to NGF because they lack the signal transducing NGF receptor, trkA. We have previously shown that acquisition of trkA expression is sufficient to confer afunctional response to NGF. Here we describe four subpopulations of thoracolumbar sympathetic neuroblasts which are mitotically active and unresponsive to NGF at E13.5 of rat gestation, but differ based upon their neurotrophic responsiveness in vitro. The survival in culture of the largest sympathetic subpopulation is mediated by neurotrophin-3 (NT-3) or glial-derived neurotrophic factor (GDNF), whereas the cell survival of two smaller subpopulations of neuroblasts are mediated by either solely GDNF or solely NT-3. Finally, we identify a subpopulation of sympathetic neuroblasts in the thoracolumbar region whose survival, exit from the cell cycle, induction of trkA expression, and consequent acquisition of NGF responsiveness in culture appear to be neurotrophin independent and cell autonomous. These subpopulationsreflect the diversity of neurotrophic actions that occur in the proper development of sympathetic neurons. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 12:52:02