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Titolo:
Role of immunological lymphocyte subset typing as a screening method for lymphoid malignancies in daily routine practice
Autore:
Thalhammer-Scherrer, R; Veitl, M; Exner, M; Schneider, B; Geissler, K; Simonitsch, I; Schwarzinger, I;
Indirizzi:
Univ Vienna, Dept Lab Med, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 , Dept Lab Med, A-1090 Vienna, Austria Univ Vienna, Dept Med Stat, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 Dept Med Stat, A-1090 Vienna, Austria Univ Vienna, Dept Med 1, Div Hematol & Hemostaseol, A-1090 Vienna, AustriaUniv Vienna Vienna Austria A-1090 & Hemostaseol, A-1090 Vienna, Austria Univ Vienna, Dept Clin Pathol, A-1090 Vienna, Austria Univ Vienna ViennaAustria A-1090 pt Clin Pathol, A-1090 Vienna, Austria
Titolo Testata:
CYTOMETRY
fascicolo: 1, volume: 42, anno: 2000,
pagine: 5 - 10
SICI:
0196-4763(20000215)42:1<5:ROILST>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL SUBSETS; SYSTEMIC LUPUS-ERYTHEMATOSUS; CANADIAN CONSENSUS RECOMMENDATIONS; CHRONIC-FATIGUE-SYNDROME; PERIPHERAL-BLOOD; FLOW-CYTOMETRY; IMMUNOPHENOTYPIC ANALYSIS; RENAL-TRANSPLANTATION; HEMATOLOGIC NEOPLASIA; RHEUMATOID-ARTHRITIS;
Keywords:
flow cytometry; blood lymphocyte subsets; lymphoma; diagnostic efficacy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Schwarzinger, I Univ Vienna, Dept Lab Med, Waehringer Guertel 18-20, A-1090 Vienna, Austria Univ Vienna Waehringer Guertel 18-20 Vienna Austria A-1090
Citazione:
R. Thalhammer-Scherrer et al., "Role of immunological lymphocyte subset typing as a screening method for lymphoid malignancies in daily routine practice", CYTOMETRY, 42(1), 2000, pp. 5-10

Abstract

Background: The major diagnostic role of peripheral lymphocyte subset typing is to distinguish between malignant and reactive conditions,Methods: The present study evaluates the screening efficacy of flow cytometric lymphocyte subset typing for the presence of a lymphoid malignancy. Four hundred samples were analyzed with a combination of anti-T-, B-, and natural killer (NK)-cell monoclonal antibodies. Results: Two hundred and twenty (55%) samples showed a normal distributionof lymphocyte subsets, 73 (18%) samples exhibited unspecific alterations of lymphocyte subsets, 19 (5%) samples exhibited a reactive phenotype typical of Epstein-Barr virus/cytomegalovirus (EBV/CMV) infection, and 88 (22%) samples expressed a phenotype suggestive of lymphoma. The most predictive independent factor of a lymphoma-specific phenotype was the absolute lymphocyte count (P = 0.0001, odds ratio 73.225), Seventy-eight percent of samples containing greater than or equal to 4 x 10(9)/l lymphocytes and 2% of samples with lymphocyte counts <4 x 10(9)/l exhibited a lymphoma-specific phenotype, The specificity of the referring clinical comment was the second best predictor of a lymphoma-specific typing outcome (P = 0.0001, odds ratio 19.589), The independent predictive values of lymphocyte morphology and of relative lymphocyte counts were of borderline significance. Conclusions: The use of flow cytometric lymphocyte subset typing as a diagnostic screening method for lymphoma should be restricted to cases of unexplained elevation of absolute lymphocyte counts with or without morphological atypias and to cases with definite clinical symptoms of lymphoma. (C) 2000 Wiley-Liss, Inc.

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Documento generato il 05/12/20 alle ore 00:34:56