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Titolo:
Retrograde axonal transport impairment of large- and medium-sized retinal ganglion cells in diabetic rat
Autore:
Zhang, LX; Ino-ue, M; Dong, K; Yamamoto, M;
Indirizzi:
Kobe Univ, Sch Med, Dept Ophthalmol, Chuo Ku, Kobe, Hyogo 6500017, Japan Kobe Univ Kobe Hyogo Japan 6500017 l, Chuo Ku, Kobe, Hyogo 6500017, Japan Kobe Univ, Sch Med, Dept Anat 1, Chuo Ku, Kobe, Hyogo 6500017, Japan Kobe Univ Kobe Hyogo Japan 6500017 1, Chuo Ku, Kobe, Hyogo 6500017, Japan
Titolo Testata:
CURRENT EYE RESEARCH
fascicolo: 2, volume: 20, anno: 2000,
pagine: 131 - 136
SICI:
0271-3683(200002)20:2<131:RATIOL>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; OPTIC-NERVE; PATTERN ELECTRORETINOGRAM; ALDOSE REDUCTASE; PERIPHERAL-NERVE; NEUROPATHY; RETINOPATHY; GLUTAMATE; GLAUCOMA; ISCHEMIA;
Keywords:
diabetes mellitus; Fluoro-Gold labeling; retrograde axonal transport; retinal ganglion cell; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Ino-ue, M Kobe Univ, Sch Med, Dept Ophthalmol, Chuo Ku, 7-5-1 Kusunoki Cho, Kobe, Hyogo 6500017, Japan Kobe Univ 7-5-1 Kusunoki Cho Kobe Hyogo Japan 6500017 017, Japan
Citazione:
L.X. Zhang et al., "Retrograde axonal transport impairment of large- and medium-sized retinal ganglion cells in diabetic rat", CURR EYE R, 20(2), 2000, pp. 131-136

Abstract

Purpose. Several abnormalities in visual pathway functions in diabetic humans and animals have been reported. We demonstrated retrograde axonal transport impairment in retinal ganglion cells of streptozotocin-diabetic rats. Methods. Diabetes was induced in male Wistar albino rats by intraperitoneal injection of streptozotocin. Three months after the induction of diabetes, fluoro-gold was injected into the dorsal lateral geniculate nucleus. Percentages of fluoro-gold-labeled large-, medium- and small-sized retinal ganglion cells per total population were calculated in wholemount retinas of diabetic and control rats. The same sections were stained with cresyl violet and each retinal ganglion cell type evaluated by light microscopy. Results. Although a quantitative decrease in the population of each retinal ganglion cell type was not observed, mean percentages of fluoro-gold-labeled large- and medium-sized retinal ganglion cells per total population were significantly decreased in diabetic rats compared with controls. Conclusions. Our results suggest that diabetes affects the retrograde axonal transport in large- and medium- sized retinal ganglion cells despite theabsence of morphological changes in the perikaryon and decrease in total cell population. Diabetes-induced impairment of retrograde axonal transport in large- and medium-sized retinal ganglion cells precede optic nerve involvement. However, this may merely be a consequence of metabolic changes in diabetic states.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 17:34:48